Endocrine Abstracts

Introduction: Type 2 diabetes mellitus (T2DM) frequently associates with increasing multi-morbidity/treatment complexity. Some headway has been made to identify genetic and non-genetic risk factors for T2DM. However longitudinal clinical histories of individuals both before and after diagnosis of T2DM are likely to provide additional insight into both diabetes aetiology/further complex trajectory of multi-morbidity.Methods: This study utilised diabetes p...

Introduction: The androgen receptor (AR) mediates the peripheral effects of testosterone. The main mechanism of action for the AR is direct regulation of gene transcription. Available evidence suggests that the number of CAG repeats in exon-1 of the AR gene is negatively correlated with transcriptional activity of the AR and that CAG repeat number links to mortality rate in T2DM men. The aim of this analysis was to determine the association between CAG repeat number and all ca...

Introduction: CACNA1C gene encodes the L-type voltage dependent calcium channels and its variants are associated with susceptibility to psychiatric disorders. We recently provided evidence of a genotype-by-environment interaction of the CACNA1C rs1006737 polymorphism, suggesting that the cortisol awakening response (CAR), an indicator of HPA-axis function, might be increased in non-risk allele carriers (GG) who have experienced childhood trauma (CT). In these...

Introduction: There is growing evidence of external factors modulating epigenetic modifications and their contribution to the development of obesity and T2DM. One of the epigenetic signatures is DNA methylation. We investigated whether a lifestyle intervention could influence DNA methylation of Brain derived neurotrophic factor (BDNF) in individuals with IGR, as BDNF is thought to play an important role in glucose metabolism.Methods: IGR participants (<e...

Background: Bariatric surgery (BS) results in metabolic pathway recalibration. When major metabolic change occurs, blood protein components have a key role and can be altered significantly. We set out to identify potential biomarkers of change in plasma following BS in people achieving remission of type 2 diabetes mellitus (T2DM).Methods: Longitudinal analysis was performed on serum samples from 10 individuals who all achieved remission of T2DM following...

Background: Bariatric surgery (BS) can have significant effects on multiple body systems and has been an effective intervention for morbid obesity, improving many comorbid medical conditions that are associated with mental health and cognitive dysfunction. It was previously shown that cognitive impairment was partly reversible in obese patients after BS [1], however, the effects of BS on proteins associated to central nervous system (CNS) still unknown. We evaluated if there a...

Aims: We used sequential window acquisition of all theoretical fragment ion spectra Mass Spectrometry (SWATH-MS) to identify proteins acting as markers of remission of type 2 diabetes (T2DM) in patients who lost weight after bariatric surgery.Background: Bariatric surgery results in remission of T2DM in up to 80% of patients. The mechanisms underpinning are largely unknown. N-acetylmuramoyl-L-alanine amidase (PGLRYP2) is an immune response enzyme that br...

Introduction: Hypogonadism is associated with poorer glycaemic outcomes/increased all cause and cardiovascular morbidity/mortality in type 2 diabetes mellitus (T2DM). Increasing CAG repeat number within exon 1 of the androgen receptor gene is associated with increased androgen receptor resistance/insulin resistance. We here investigated the link between CAG repeat number and outcomes in T2DM men.Methods: We determined in a long-term 14-year follow-up coh...