Searchable abstracts of presentations at key conferences in endocrinology

ea0022p660 | Neuroendocrinology and Pituitary (<emphasis role="italic">Generously supported by Novartis</emphasis>) | ECE2010

Trends in acromegaly treatment in Spain

Sesmilo Gemma , Gaztambide Sonia , Pico Antonio , Soto Alfonso , Torres Elena , Fajardo Carmen , Blanco Concepcion , Webb Susan

The Spanish acromegaly registry (REA) is an online epidemiological database created in 1997 to collect clinical and biochemical data of patients with acromegaly followed in Spain.Aim: To study trends in acromegaly treatment over time in Spain.Methods: REA is an online database in which registered endocrinologists collect data from all acromegalic patients seen at their practices in Spain. In the last year the neuroendocrine group o...

ea0016p479 | Neuroendocrinology | ECE2008

Familial acromegaly: family screening and assessment in the familial isolated pituitary adenoma (FIPA)

Fajardo Carmen , Daly Adrian , Trescoli Carlos , Camara Rosa , Riesgo Pedro , Gomez Jose , Beckers Albert

Familial acromegaly (FA) is a rare disease with less than 150 cases published. For its diagnosis (FA), two or more cases of acromegaly in the same family and the absence of MEN1 and/or Carney syndrome are required. FA is in the familial isolated pituitary adenomas (FIPA) group although its genetic condition is still under investigation.The index case is an asymptomatic 43-year-old woman with a 4mm pituitary micro-adenoma. There were not acromegaly signs/...

ea0056gp138 | Neuroendocrinology | ECE2018

Hypermethylation of tumour suppressor genes in pituitary adenomas: contribution to oncogenesis and tumour behaviour

Garcia-Martinez Araceli , Sottile Johana , Fajardo Carmen , Camara Rosa , Lamas Cristina , Pico Antonio

Introduction: Epigenetic and genetic alterations contribute to cancer initiation and progression. These alterations may be playing a determinant role in the development of pituitary adenomas (PAs). One of these epigenetic processes is the DNA methylation and, specifically, methylation of Tumour Suppressor Genes (TSG). TSG are key elements that allow the maintenance of cellular homeostasis. Due to epigenetic changes are reversible, a better understanding of the underlying epige...

ea0063gp167 | Obesity (1) | ECE2019

Epigenetic regulation by miRNAs in corticotroph tumors

Garcia-Martinez Araceli , Lopez-Munoz Beatriz , Fajardo Carmen , Camara Rosa , Lamas Cristina , Torregrosa Maria Eugenia , Aranda Ignacio , Pico Antonio

Introduction: The silencing mechanisms of corticotroph tumors (CT) remain unclear. The most feasible hypothesis lies in a post-transcriptional deregulation of the POMC gene, precursor of ACTH. Micro RNAs (miRNAs) are small non-coding RNA molecules involved in the epigenetic regulation of gene expression through their inhibitory action on messenger RNA. miRNAs capable of inhibiting the expression of POMC have been described at the level of neurons of the hypot...

ea0063p715 | Pituitary and Neuroendocrinology 2 | ECE2019

Silent somatotroph tumors

Garcia-Martinez Araceli , Lloret Adriana , Torregrosa Maria Eugenia , Silva Sandra , Lamas Cristina , Fajardo Carmen , Camara Rosa , Aranda Ignacio , Pico Antonio

Introduction: Silent somatotroph tumors (sST) are a pituitary neuroendocrine tumor subtype with positive immunostaining for growth hormone (GH) but without the presence of acromegaly. Unlike silent corticotroph tumors, there is little information in the literature on sST. The aim of the present study was to study the demographic, clinical and molecular characteristics in a series of ST in order to compare sST and functioning ST (fST).Methods: We have stu...

ea0037gp.18.08 | Pituitary–Basic and IGF-1 | ECE2015

Role of miR-375 in oncogenesis of pituitary adenomas

Sanchez-Tejada Laura , Sanchez-Ortiga Ruth , Riesgo Pedro , Abarca Javier , Fajardo Carmen , Monjas Irene , Camara Rosa , Lamas Cristina , Pico Antonio

Purpose: MicroRNAs (miRNAs) are a fundamental component of gene regulation mechanisms. Presently, altered miRNA patterns of expression have been documented in different human cancers, and they may explain the distinct behavior of pituitary adenomas (PA) and the differences between subtypes. miR-375 can target among other genes to IGF1 receptor (IGF1R) and participes in reprogramming cancer cell metabolism. The aim of this study was to assess the miR-375 role on pathogenesis of...

ea0037gp.18.09 | Pituitary–Basic and IGF-1 | ECE2015

Molecular classification of pituitary adenomas

Pico Antonio , Sanchez-Tejada Laura , Sanchez-Ortiga Ruth , Camara Rosa , Lamas Cristina , Abarca Javier , Monjas Irene , Riesgo Pedro , Fajardo Carmen

Purpose: The 2004 edition of the WHO text ‘Histological typing of endocrine tumors’ classified pituitary adenomas (PA) on the basis of their histological and immunohistochemical characteristics. Recent advances on the knowledge of the molecular patterns of these tumours may allow establishing a molecular classification with higher accuracy and specificity than previous one.Methods: Within the pale of the multicenter Spanish Molecular Registry o...

ea0037gp.21.06 | Pituitary – Diagnosis of Cushing's disease | ECE2015

Prolactine and urinary free cortisol measurement improve inferior petrosal sinus sampling results in ACTH dependent Cushing's Syndrome

Montanana Carmen Fajardo , Navarro Lucia Camarena , Puchol Ma Dolores Ferrer , Ortiz Carmen Valldecabres , Vela Jose Gomez , Suarez Pedro Riesgo

Introduction: Inferior petrosal sinus sampling (IPSS) is considered to be the gold standard for confirming the source of ACTH secretion in patients with Cushing’s syndrome (CS). Prolactin measurement during IPSS can improve diagnostic accuracy and reduces false negative responses.Patients and methods: 56 patients with ACTH-dependent CS were included (45 F/11 M, mean age 43.6±10.8 years and 90.1% Cushing’s disease) diagnosed since 2000. IPS...

ea0037ep669 | Pituitary: basic and neuroendocrinology | ECE2015

MiR-7 has a role in behaviour of somatotroph adenomas

Sanchez-Ortiga Ruth , Sanchez-Tejada Laura , Lamas Cristina , Camara Rosa , Abarca Javier , Monjas Irene , Riesgo Pedro , Fajardo Carmen , Pico Antonio

Purpose: IGF receptor 1 (IGF1R) and epidermal growth factor receptor (EGFR) are receptors tyrosine-kinase (RTK) whose altered signaling are critical factors in development of many types of tumours. These RTK are some of the main targets of the microRNA miR-7. This important tumor supressor miRNA has the ability to inhibit the motility, invasiveness and anchorage-independent growth, suggesting a strong therapeutic potential in many types of cancer. Pituitary adenomas (PA) are a...

ea0056gp139 | Neuroendocrinology | ECE2018

Why don’t corticotroph tumours always produce Cushing disease?

Garcia-Martinez Araceli , Cano David , Gil Joan , Fajardo Carmen , Camara Rosa , Lamas Cristina , Soto Alfonso , Puig Manel , Webb Susan M

Introduction: Silent corticotroph tumours (SCT) are a pituitary tumours (PT) subtype of corticotroph lineage that do not clinically express Cushing disease. Inmunohistochemical (IHC) studies reveal no differences between SCT and functioning corticotroph tumours with Cushing Syndrome (FCT). However, the silencing mechanisms of this type of tumours are not fully understood.Aim: In an important series of SCT, to sequence the POMC gene and quantify ...