Searchable abstracts of presentations at key conferences in endocrinology

ea0074ncc46 | Highlighted Cases | SFENCC2021

Recurrence of cushing’s disease after several years of remission

Ganawa Shawg , Kearney Tara

68 Y M Has Background of Hypertension and Asthma. Presented with progressive visual deterioration for 12 months in 2012. VF testing confirmed Bitemporal Hemianopia. He has symptoms suggestive of cortisol excess. Therefore, MRI pituitary and pituitary hormone profile was done. MRI showed pituitary macroadenoma A Pituitary Hormone profile in 2012 showed cortisol excess at value of 755 nmol/l and ACTH 156 ng/l(0–46). IGF-1 17.2 nmol/l which is normal. LDDST was done and cortisol ...

ea0082wd6 | Workshop D: Disorders of the adrenal gland | SFEEU2022

Acute presentations of 4 patients with spontaneous adrenal haemorrhage

Ganawa Shawg , Ensah Grace , Keevil Brian , Issa Basil

: We report on 4 patients who acutely presented to our unit and diagnosed with adrenal haemorrhage.Case 1: A 72 year old man presented with generalised abdominal pain, fever and raised CRP a week after hip replacement surgery. CT abdomen showed non-enhancing bilateral adrenal lesions consistent with adrenal haemorrhage. He was taking Apixaban for DVT following hip replacement. SST was performed which confirmed suboptimal cortisol response. Hence, Treated...

ea0082wg1 | Workshop G: Disorders of appetite and weight | SFEEU2022

GLP1RA therapy in Bardet-Biedl syndrome

Ganawa Shawg , Santhosh Smrithi , Parry Lucy , Syed Akheel A.

Background: Bardet-Biedl syndrome (BBS) is a rare genetic condition characterised by ciliary protein dysfunction leading to multi-organ damage. Patients with BBS can suffer from hyperphagia and severe obesity from childhood and associated weight-related comorbid diseases such as type 2 diabetes and hypertension. However, the optimal weight management strategy and response to weight loss pharmacotherapy is unknown. Case presentation: We present a case of ...

ea0090p666 | Endocrine-related Cancer | ECE2023

A rare case of immunotherapy related adrenalitis

Ganawa Shawg , Mashamba Chiedza , Ilyas Waqas , Higham Claire , Cooksley Tim , Hoong Ho Jan , Adam Safwaan , Dhage Shaishav

Introduction: Immunotherapy has transformed the outcomes of various cancers. Monoclonal antibodies against cytotoxic T lymphocyte antigen 4 (CTLA4), programmed cell death 1 (PD1) and its ligand, PDL1 target mainly T cells, unleashing the immune system against tumour cells. Immune checkpoint inhibitor therapy results in a variety of immune related adverse events, including various endocrinopathies. Thyroid disorders, pituitary disorders are relatively more common compared to pr...

ea0086p45 | Endocrine Cancer and Late Effects | SFEBES2022

Emergency Ambulatory Outpatient Management of Immune Checkpoint Inhibitor-mediated Hypocortisolaeamia

Ganawa Shawg , Muhammad Haris , Knight Tom , Dhage Shaishav , Hoong Ho Jan , Gupta Avinash , Lorigan Paul , Higham Claire , Cooksley Tim , Adam Safwaan

Background: Immunotherapy mediated adrenocorticotrpic hormone (ACTH) deficiency is an important toxicity related to immune-checkpoint inhibitors (ICPi) potentially resulting in significant morbidity. Early diagnosis and optimal management are essential and frequently necessitate inpatient hospital treatment. We have previously reported an ambulatory management pathway for ICPi-induced ACTH deficiency in 4 patients. We sought to report the outcomes of this pathway in a larger c...

ea0090ep732 | Pituitary and Neuroendocrinology | ECE2023

Pituitary metastasis in neuroendocrine neoplasms, lesson learned from cases reports

Ganawa Shawg , Ilyas Waqas , Irshad Shadman , Hamad Adeel , Pathmanaban Omar , Milanovic Dusan , Colaco Rovel , Blackhall Fiona , Valle Juan , Ho Jan Hoong , Adam Safwaan

Introduction: Pituitary metastases (PM) are an uncommon manifestation of Neuroendocrine neoplasms (NENs) and are rarely reported. We report two cases of PM with different clinical lessons.Case 1: A 37-year-old female underwent surgical resection for a high grade poorly differentiated neuroendocrine carcinoma of the cervix (Ki67 90%). Serial follow-up surveillance assessments revealed disease progression (local, liver, lung, and bone) for which she underw...