Searchable abstracts of presentations at key conferences in endocrinology

ea0014s9.2 | Imaging in endocrinology | ECE2007

Macro-, micro-, and molecular imaging of bone

Glüer Claus-C.

The clinical diagnostic examination of patients and the research-oriented investigation of the pathophysiology of skeletal disorders require imaging techniques that allow to visualize the skeleton at different scales: from the organ level to tissue, cellular, and subcellular levels, depicting morphology and function. Progress in the field of imaging technologies resulted in methods suited for clinical investigation of patients in vivo, non-invasive methods for preclinical anim...

ea0054is14 | (1) | NuclearReceptors2018

The structural basis of chromatin reprogramming by steroid receptors

Hager GL , Paakinaho V , Johnson TA , Chereji RV , Clark DJ , Swinstead EE , Presman DM

Localized transitions in chromatin structure accompany nuclear receptor binding events in mammalian cells. These remodeling processes are critical to determine the binding landscape for steroid receptors (SRs) in cancer cells. Multiple reports indicate that steroid receptors (ER, GR, AR, PR) can regulate the binding patterns for each other, particularly during cancer progression. Elucidation of the mechanisms by which these ‘chromatin opening’ processes occur is cent...

ea0011p59 | Clinical case reports | ECE2006

The coincidence of mucoepidermoid and papillary thyroid carcinoma. A case report

Kovacs GL , Salamon F , Gorombey Z , Kovacs L , Hubina E , Goth MI , Szabolcs I

We report the case of a 55 years old female patient with parallel appearance of mucoepidermoid carcinoma and papillary thyroid carcinoma. She had autoimmune adrenal insufficiency and a pulmonary adenocarcinoma cured by lobectomy and external irradiation six years before. She had been referred to our department because of a rapidly growing thyroid nodule. Aspiration cytology suspected papillary tumor and a tumor of non-thyroid origin as well. Thyroidectomy and bilateral neck ly...

ea0054is10 | (1) | NuclearReceptors2018

Modulating glucocorticoid receptor function in breast and prostate cancer

Tonsing-Carter E. , Long T. , West D.C. , Harkless R. , Dolcen D.N. , Hosfield D. , Greene G.L. , Szmulewitz R.Z. , Conzen S.D.

In normal physiology, glucocorticoid receptor (GR) activation regulates cell type-dependent genes whose products influence metabolism, inflammation, cell cycle and apoptosis/cell survival pathways. Synthetic GR agonists, or glucocorticoids (GCs), are often used to treat hematologic malignancies because of GR’s ability to induce proapoptotic gene expression, inhibit nuclear factor–κB, and induce cell cycle arrest. In contrast, recent examination of GR expression ...

ea0054p5 | (1) | NuclearReceptors2018

Glucocorticoid receptor inhibits ER-mediated pro-proliferative gene expression

Tonsing-Carter E , Kim CR , Hernandez KM , Bowie KR , West DC , Chandarlapaty S , Greene GL , Conzen SD

Early-stage ER+ breast cancer (BC) with high tumor glucocorticoid receptor (GR) expression is associated with improved long term relapse-free survival compared to tumors with low GR expression. In addition, GR activity inhibits ER-mediated BC cell proliferation. We therefore hypothesized that GR and ER engage in nuclear receptor crosstalk to influence pro-proliferative gene expression, thus contributing to a better outcome in ER+/GR+ breast cancer. To understand the mechanisms...

ea0014p282 | (1) | ECE2007

Correlation of BclI, N363S and the ER22/23EK polymorphisms of the glucocorticoid receptor gene and bone mineral density in patients with endogenous and exogenous hypercortisolism

Szappanos Ágnes , Toke Judit , Boyle Belema , Majnik Judit , Varga Ibolya , Gláz Edit , Tóth Miklós , Rácz Károly

Objective: Genetic variation in the glucocorticoid receptor (GR) gene may be related to the clinical heterogenety and severity of the Cushing’s syndrome. BclI, N363S and ER22/23EK polymorphisms are the three most investigated polymorphisms within the GR gene, however, the importance and magnitude of their effect in hypercortisolemic states are unclear. The BclI and the N363S variants are associated with increased, while the ER22/23EK variant is associated with reduced glu...

ea0011p530 | Endocrine tumours and neoplasia | ECE2006

18F-deoxy-D-glucose positron emission tomography (FDG_PET) increases the detection rate of recurrent or residual medullary thyroid cancer

Faggiano AF , Ferolla PF , Pezzullo LC , Chiofalo MC , Milone FM , Mozzillo NM , Scarpelli GS , Santeusanio FS , Angeletti GA , Lombardi GL , Colao AC

Surgical treatment is the first therapeutic option in patients affected with medullary thyroid carcinoma (MTC). However, cure-rates are often low due to the high frequency of loco-regional metastases and recurrences. Therefore, post-operative hyper-calcitoninemia is a common feature in CMT. Despite these findings, traditional imaging techniques are often unable to localize tumour foci. In the last years the availability of new morpho-functional techniques might offer new chanc...

ea0014p163 | (1) | ECE2007

High prevalence of novel mutations of the MEN1 gene in Hungarian patients with multiple endocrine neoplasia type 1

Balogh Katalin , Hunyady László , Patócs Attila , Gergics Peter , Valkusz Zsuzsa , Tóth Miklós , Varga Ibolya , Gláz Edit , Rácz Károly

Introduction: Multiple endocrine neoplasia type 1 (MEN 1) may present as a familial or a sporadic disorder with multiple endocrine tumours including parathyroid adenomas or hyperplasias, tumours of endocrine pancreatic and pituitary gland. Familial and sporadic MEN 1-related states which do not fulfill current diagnostic criteria but may be related to MEN 1 syndrome have been also described.Aims: The aim of this study was to examine the prevalence and sp...

ea0073aep62 | Adrenal and Cardiovascular Endocrinology | ECE2021

Patients with congenital adrenal hyperplasia show an adverse cardiovascular risk profile compared to patients with autoimmune adrenalitis

Hannes Beiglböck , Magdalena Bögl , Fellinger Paul , Metz Matthaeus , Vila Greisa , Luger Anton , Trattnig Siegfried , Kautzky-Willer Alexandra , Krssak Martin , Krebs Michael , Peter Wolf

BackgroundDespite adequate hormone replacement therapy, evidence suggests an increased mortality in patients suffering from primary adrenal insufficiency, mainly because of cardiovascular diseases. Congenital adrenal hyperplasia (CAH) and autoimmune adrenalitis (AI) are two entities with a different pathophysiological background and might therefore show divergent cardiovascular risk profiles.Methods9 patients...

ea0014p422 | (1) | ECE2007

Changes of serum bone marker concentrations after effective therapy of patients with Cushing’s syndrome

Tóth Miklós , Toke Judit , Lippai Dóra , Sereg Márta , Szappanos Ágnes , Füto László , Varga Ibolya , Szücs Nikolette , Kiss Róbert , Gláz Edit , Rácz Károly

Introduction: The most important feature of bone metabolism in patients with Cushing’s syndrome is the uncoupling of osteoblast and osteoclast activity resulting in suppressed bone formation.Objective: The aim of the present study was to investigate the altered bone turnover in patients with various forms of Cushing’s syndrome in the active phase of the disease as well as after successful normalization of cortisol overproduction.<p class="a...