Endocrine Abstracts

The diagnosis of hypogonadism in a young person represents reduced sex steroid production and subfertility.Optimising sex steroid replacement both in terms of preparation and dose occurs after pubertal induction. Clinical practice has changed in the UK in respect to females. The management of subclinical hypogonadism and benefits of testosterone replacement in male cancer survivors and klinefelter syndrome remain unclear. The endocrinologist needs to nav...

The effects of cancer therapy on pituitary and thyroid function evolve over many years and therefore careful long term screening strategies are required. Knowledge of the initial cancer diagnosis, age at diagnosis, radiation field, radiation dose and duration of follow up can aid identification of survivors most at risk.Cranial irradiation to the hypothalamic pituitary axis increases the risk of pituitary dysfunction. The most common pituitary hormone to...

Aim: To evaluate the current service provisions and provide action plan for improvement within the YAE service.Methods: A friends and family questionnaire given to all patients attending the YAE service from October 2018 – January 2019. Survey questions included: whether they thought this was a good clinic for friends and family to be looked after in, what we did well and what we could do better. For YA patients transferring from children’s s...

A forty-three year old woman (SR) presented to her GP in 2004 with persistent back pain. Following MRI, an incidental right adrenal mass was discovered. Laparoscopic adrenalectomy was performed in the private sector and histology was consistent with a phaeochromocytoma. No further biochemical investigations were performed at that stage. Six years later, her fourteen year old daughter presented with a solitary neck lump. Fine needle aspiration was inconclusive and subsequent le...

A 29 year old gentleman presented to Urology with scrotal pain. He had renal calculi but examination also revealed small testicles for which he was referred to Endocrinology. He achieved normal developmental milestones. He had no history of mumps or testicular torsion or surgery. He had no history of hypospadias or undescended testicles. He was not on any regular medication and denied anabolic steroids use. He reported a normal sense of smell. His body weight was 72 Kg with he...

Background: PCOS is a common female endocrine disorder, exacerbated by obesity. International guidelines therefore suggest weight loss as first line management. This service evaluation assessed the care pathway of patients referred to Queen Elizabeth Hospital Birmingham (QEHB) with suspected PCOS. We aimed to assess the referral wait time, reason for referral, treatment offered, and weight management in clinic.Methods: We undertook a cross-sectional stud...

Background: Transition is an important stage in the care of a young person with a long-term endocrine condition.Objective: To explore current services for young people (YP) with endocrine conditions from the perspective of paediatric and adult endocrinologists, and YP and their parents using their services.Methods: There were two components:- i). service questionnaire for completion by paediatric and adult endocrinologists ii). &#1...

Aim: To evaluate the recovery rate, characteristics and factors that might help predict the HPA axis recovery of patients with glomerulonephritis (GN) and GC-induced AI.Study Design: A retrospective study involving all GN patients referred from January 2014-December 2016 with a confirmed diagnosis of GC-induced AI with a planned weaning from conventional Prednisolone (Pred) immunosuppression and switch onto Hydrocortisone (HC). Data collected up to Novem...

Background: Errors made with critical medicines such as desmopressin and hydrocortisone used in the treatment of endocrine conditions in hospitalised patients can undermine patient safety but are largely preventable.Methods: Retrospective audit of adult patients admitted at the University Hospitals of Leicester NHS Trust between January 2013 and June 2014, prescribed desmopressin for cranial diabetes insipidus (CDI) or other medical conditions using elec...

Background: Bone marrow transplant (BMT) survivors are at increased risk of metabolic syndrome and developing type 2 diabetes (T2DM). Measurement of HbA1c is increasingly used in recent years for the diagnosis of T2DM. An HbA1c level of ≥6.5% (48 mmol/mol) is considered as a diagnostic cut-off for T2DM and an HbA1c between 6.0–6.4% (42–47 mmol/mol) is considered as at risk of T2DM. We aimed to look at the diagnostic performance of HbA1c and oral glucose toleran...