Endocrine Abstracts

Background: Endoscopic surgery (ES) performed in Pituitary Centers of Excellence (PCOE) represents the gold standard treatment for GH-secreting adenomas. However, rate of cure greatly varies according to definition criteria, follow-up duration, various patient and adenoma features, and surgeon ability.Study aim: To assess short- (3 month) and long-term (≥1 year) outcome and identify predictors of ES, in a large and homogeneous cohort of acromegaly ...

Rationale and aim: The incidence of intracranial aneurysms (IA) appears increased in patients with PAs/PitNETs. Changes in hemodynamics and vascular structure secondary to mass effect, inflammation, and hormonal changes (primarily, GH hypersecretion) have been suggested as risk factors. Study aim was to define typical features, timing of occurrence and treatment, and identify risk factors in patients with PA/PitNET and IA.Patients and methods: Data of 57...

Background: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic disease (Covid-19) affects thyroid function with different mechanisms: non-thyroidal illness syndrome (NTIS), direct infection of thyroid gland and cytokine storm. We provided the first description of painless atypical thyroiditis coexisting with NTIS in patients hospitalised for moderate-to-severe Covid-19 disease. We aimed to: 1) correlate thyroid dysfunction with Covid-19 disease severity;...

Background: In vitro and animal experiments have clearly demonstrated that excessive cortisol, GH and prolactin secretion, as well as dopamine agonists (D2As) and somatostatin analogs (SSAs), often prescribed for their treatment, affect the immune response and the onset/evolution of autoimmune diseases (AIDs) through direct and indirect complex mechanisms. Data from clinical studies are very scanty.Study aim: To assess the 1) distribution of AIDs accordi...

BackgroundWe provided the first description of thyrotoxicosis due to atypical thyroiditis in patients hospitalised for severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) pandemic disease (Covid-19), not associated with neck pain, more common in men, correlated with disease severity and coexisting with non-thyroidal illness syndrome. Classic viral subacute thyroiditis is often followed by permanent thyroid dysfunction and autoimmunity, thus we h...

Introduction: Polycystic ovary syndrome (PCOS) is highly prevalent in women with type 1 diabetes mellitus (T1DM), possibly due to premenarchal exogenous hyperinsulinism (supraphysiological doses and nonphysiologic route of insulin administration). Our aim was to determine if PCOS was related to daily or basal insulin dose or T1DM duration.Methods: We examined 47 women with T1DM (mean age 36.02 years, ±6.03) treated with continuous subcutaneous insul...