Searchable abstracts of presentations at key conferences in endocrinology

ea0037mte15 | (1) | ECE2015

Primary hyperparathyroidism (Meet-the-Expert 18)

Gurlek Alper

Primary hyperparathyroidism (PHPT) is the third common disorder of the endocrine system. It reaches a peak incidence between ages 50–60. Biochemical screening has increased its incidence up to one per 1000 (USA), and most cases are presented with asymptomatic mild hypercalcemia. The most common cause in affected individuals is a functioning single parathyroid adenoma. In advanced cases, bones (brown tumours, osteitis fibrosa cystica) and the kidney (nephrolithiasis, nephr...

ea0090p482 | Thyroid | ECE2023

Sonographic and clinicopathological differences between non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) and minimally invasive encapsulated follicular variant of papillary thyroid carcinoma (EFVPTC)

Erturk Banu , Gaye Guler Yesim , Gurlek Alper

Background: Noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) is a newly described indolent thyroid tumor with well-defined histopathological diagnostic criteria. Even though the histopathologic features and diagnostic criteria for NIFTP are well-established, preoperative diagnosis using sonographic or fine needle aspiration findings has yet to be confirmed. The aim of this study is to compare the clinical, sonographic, and cytological charac...

ea0037ep309 | Calcium and Vitamin D metabolism | ECE2015

Parathyroid hormone therapy for postoperative resistant hypocalcaemia

Akin Safak , Bayraktar Miyase , Gurlek Alper

Introduction: No consensus guideline on the treatment of hypoparathyroidism. Hypoparathyroidism is a disease characterized by hypocalcaemia and insufficient PTH. Conventional therapy includes calcium and active vitamin D supplementation, often in large doses.Case report: A 31-year-old woman presented with hypercalcemia. Serum calcium and phosphorus levels were 10.5 and 2.56 mg/dl respectively. The serum PTH level was increased (1619 pg/ml). The serum 25-...

ea0032p1006 | Thyroid (non-cancer) | ECE2013

Prevalance of GH deficiency in Turkish patients with Hashimoto's thyroiditis: a single center experience

Akin Safak , Aydin Kadriye , Gurlek Alper

Background and Aim: Prevalence of Hashimoto’s thyroiditis is increasing in Turkey. GH deficiency has been reported to associate with this disorder in several different ethnic population. The aim of this study was to evaluate GH deficiency in the population with Hashimoto’s thyroiditis.Materials and methods: Euthyroid Hashimoto’s thyroiditis patients, who admitted to the Department of Endocrinology and Metabolism of Hacettepe University, we...

ea0035p917 | Pituitary Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2014

Treating prolactinoma by endoscopic endonasal pituitary surgery: surgical experience of 151 cases

Akin Safak , Berker Mustafa , Isikay Ilkay , Gurlek Alper

Background and Aim: Prolactinoma is the most common type of functional pituitary tumor in adults. Giant prolactinomas are defined as tumors achieve a diameter >4 cm and often have very high serum prolactin level. In our previous study showed that endoscopic endonasal pituitary surgery is a very convenient procedure for the patient due to low morbidity and high efficiency. In this study we evaluated endoscopic endonasal pituitary surgery series in patients with prolactinoma...

ea0011p935 | Thyroid | ECE2006

Glutamic acid decarboxylase (GAD) and anti-tyrosine phosphatase (IA2) antibody positivity in newly-diagnosed Graves’ disease patients

Harmanci Ayla , Bayraktar Miyase , Hascelik Gulsen , Gurlek Alper

Background and aims: The type 1 DM patients who are GAD antibody positive have more risk of autoimmune thyroid disease than who are negative. In patients with autoimmune thyroid disease there is a significantly increased risk of anti-pancreatic autoimmune response as shown by increased GAD antibody positivity compared to normal population. However, the linkage between IA2 and thyroid autoimmunity is evaluated in one studied. Our aim is to evaluate the frequency of presence of ...

ea0081p750 | Thyroid | ECE2022

BRAFV600E, NRAS, TERT promoter mutations and correlations with clinicopathological features and distant metastasis in Turkish patients with papillary thyroid carcinoma

Yılmaz Ezgi , Gaye Guler Tezel Yesim , Kurtulan Olcay , Karkaya Jale , Tuncel Murat , Gurlek Alper

Background: Various molecular mechanisms play a role in the pathogenesis of papillary thyroid cancer(PTC). Understanding the underlying pathogenesis and genetic changes is needed to improve clinical outcomes in PTC. In this study, it was aimed to determine the frequency of, BRAF V600E TERT promoter and NRAS mutations in Turkish patients with papillary thyroid cancer, the relationship of mutations between clinicopathological features and distant met...

ea0063p1024 | Interdisciplinary Endocrinology 2 | ECE2019

Association of the Period3 clock gene polymorphism with adrenocorticotropin-stimulated cortisol levels among patients with autoimmune thyroid disease

Helvaci Nafiye , Oguz Seda , Kabacam Serkan , Karabulut Erdem , Akbiyik Filiz , Alikasifoglu Mehmet , Gurlek Alper

Background: Immune function and responses are tightly regulated by the circadian clock system and hypothalamic-pituitary-adrenal (HPA) axis. Accumulating evidence supports that there is a strong mutual relationship between these two regulatory systems at multiple levels. Recent publications suggest that the clock system may also regulate glucocorticoid release from adrenal glands by altering the sensitivity of the adrenal cortex to adrenocorticotropic hormone (ACTH).<p cla...

ea0049gp212 | Thyroid 2 | ECE2017

Association of the Period3 clock gene polymorphism with autoimmune thyroid diseases

Helvaci Nafiye , Oguz Seda , Kabacam Serkan , Karabulut Erdem , Akbiyik Filiz , Alikasifoglu Mehmet , Gurlek Alper

Background: Circadian rhythmicity is generated by a set of genes including Period3. Changes in the expression of Period3 and other clock genes have been linked with regulation of the immune system. Period3 polymorphisms have been associated with circadian disruption and so immune system dysregulation and altered secretion of several cytokines, which can lead to inflammatory and autoimmune disorders.Aim: To investigate the influence of a polymorphism in P...

ea0035p48 | Adrenal cortex | ECE2014

Retrospective analysis of adrenal ıncidentalomas: a single center experience

Akin Safak , Helvaci Nafiye , Dagdelen Selcuk , Yildiz Bulent Okan , Gurlek Alper , Erbas Tomris , Bayraktar Miyase

Background and aim: Incidentally discovered adrenal masses (adrenal incidentalomas (AI)), generally 1 cm or more in diameter, are mostly benign and asymptomatic and are often considered as nonfunctional tumors. The aim of this study was to perform the imaging characteristics, endocrinologic screening and histologic diagnoses of adrenal incidentaloma cases encountered in our institute.Methods: This retrospective evaluation of patients with AI includes 543...