Searchable abstracts of presentations at key conferences in endocrinology

ea0026p623 | Clinical case reports | ECE2011

IGF2 producing prostate tumour causing severe hypoglycaemia: case report

Barta Gy , Vadasz J , Krasznai G , Zalatnai A , Fink L

Introduction: The IGF1 and 2 are polypeptides that share structural similarities to insulin and affect carbohydrate metabolism mainly by activating the IGF1 receptor. We report a patient presenting with prostate tumour and severe hypoglycaemia.Case presentation: An 82-year-old male presented with frequent seizures and severe hypoglycaemia. Four year prior to the current presentation the patient had been diagnosed with prostate carcinoma, however, he refu...

ea0014p586 | (1) | ECE2007

The role of G-protein- and β-arrestin dependent signaling mechanisms in the tonic regulation of prolactin secretion

Oláh Márk , Szepesi Zsuzsanna , Bodnár Ibolya , Nagy György M. , Tidrenczel Zsolt

It is well known that hypophyseotrophic dopamine (DA) exhibits a tonic inhibitory effect on pituitary lactotrops in vivo. We have previously observed that prolactin (PRL) cells obtained from lactating rats become partially resistant to DA following a brief suckling period compared to non-suckled control female rats. This, so-called “desensitization” (and a parallel appearance of “tolerance”) to DA is mediated through by a selective change of protein phospha...

ea0099p97 | Endocrine-Related Cancer | ECE2024

Spontaneous and treatment-related changes in calcitonin doubling rate of medullary thyroid cancer. Long-term experience in a patient with multiple endocrine neoplasia type 2B

Tőke Judit , Reti Zsuzsanna , Garami Miklos , Kalina Ildiko , Kiss Gergely , Sapi Zoltan , Tabak Adam Gy. , Toth Miklos

Introduction: Medullary thyroid carcinoma (MTC) in multiple endocrine neoplasia type 2B (MEN2B) syndrome is associated with RET mutation. Patients harbouring de novo mutations are usually diagnosed in more advanced stages of the disease. We present the case of a young female patient with MEN2B diagnosed with stage IV medullary thyroid carcinoma at the age of 10 years.Aim: Characterizing the efficacy of the different sequences of therapies and disease pro...

ea0070aep7 | Adrenal and Cardiovascular Endocrinology | ECE2020

Investigation of angiotensin II induced gene expression changes in vascular smooth muscle cells

Balla András , Szalai Laura , Gém Janka , Kovács Kinga , Szakadáti Gyöngyi , Hunyady László

The angiotensin II (AngII) hormone exerts a number of biological effects through the type 1 angiotensin II receptor (AT1R). One of the main targets of AngII are vascular smooth muscle cells, their stimulation activates many signaling pathways and results in gene expression changes.Affymetrix Gene Chip experiments were performed to analyze the effects of AngII stimulation on gene expression. For the determinations, aortic thoracic aorta from young male Wi...

ea0014p156 | (1) | ECE2007

MEN2B – Two simultaneous cases of a rare syndrome

Sallai Ágnes , Hosszú Éva , Gergics Péter , Tulassay Zsolt , Rácz Károly , Fekete György

A 17-year-old boy was referred to our Department. In his medical history Crohn’s disease had been supposed because of abdominal pain and distention. He had previously undergone minor surgery as having large tongue with neuromas and hypertrophic gums. Due to his marfanoid appearance, arachnodactyly, massive eyebrows and lips together with his medical history, multiple endocrine neoplasia type 2B (MEN2B) was suspected, which is a very uncommon hereditary disease. It consist...

ea0014p593 | (1) | ECE2007

The effects of salsolinol on the peripheral sympathetic activity of hypophysectomized, adrenalectomized and medullectomized rats

Székács Dániel , Bodnár Ibolya , Nagy György M , Fekete Márton IK

Salsolinol (1-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline), is a recently identified endogenous prolactin (PRL) releasing factor. Salsolinol (SALS) seems to be a selective and potent stimulator of PRL secretion both in vivo and in vitro. 1-Methyl dihydroisoquinoline (1MeDIQ) is an antagonist of salsolinol induced prolactin release and causes increase in plasma norepinephrine (NE) level. SALS decreased the peripheral tissue dopamine (DA) level dose depende...

ea0014p420 | (1) | ECE2007

Changes of bone metabolism at the onset of puberty

Csákváry Violetta , Toldy Erzsébet , Puskás Tamás , Kovács Gábor L. , Oroszlán György

Object: Adolescence is the period during which the greatest accrual of bone mineral occurs. During puberty, changes of bone metabolism primarily depend on maturity. Diagnosis and therapy of childhood bone diseases is difficult due to the lack of reference ranges of metabolic bone markers. Our aim was to establish the reference values of bone markers in primary school students (mean age: 13.2±1.2 years; 65 girls, 56 boys).Methods: The children were d...

ea0073aep634 | Thyroid | ECE2021

Evaluation of fetuin-A levels in patients with autoimmune thyroiditis

Eszter Berta , Sándor Halmi , Inez Mercédesz Lengyel , Mónika Katkó , Harangi Mariann , V Nagy Endre , György Paragh , Miklós Bodor

BackgroundHypothyroidism due to autoimmune thyroiditis (AITD) leads to atherogenic lipid profile and therefore might increase the cardiovascular risk of patients. Fetuin-A is a hepatokine with a role in the regulation of mineralization, metabolism and the cardiovascular system. Fetuin-A levels are known increased in obesity-linked diseases. To date, the role of fetuin-A in autoimmune thyroiditis has not been thoroughly investigated.<p class="abstext"...

ea0054is13 | (1) | NuclearReceptors2018

Enhancers mapping uncovers phenotypic heterogeneity and evolution in patients with luminal breast cancer

Patten Darren K , Corleone Giacomo , Győrffy Balazs , Erdős Edina , Saiakhova Alina , Goddard Kate , Vingiani Andrea , Shousha Sami , Pongor Lőrinc Sandor , Hadjiminas Dimitri J , Schiavon Gaia , Barry Peter , Palmieri Carlo , Coombes Raul C , Scacheri Peter , Pruneri Giancarlo , Magnani Luca

The degree of intrinsic and interpatient phenotypic heterogeneity and its role in tumour evolution is poorly understood. Phenotypic divergence can be achieved via the inheritance of alternative transcriptional programs. Cell-type specific transcription is maintained through the activation of epigenetically-defined regulatory regions including promoters and enhancers. In this work, we annotated the epigenome of 47 primary and metastatic oestrogen-receptor (ERα)-positive br...

ea0014p585 | (1) | ECE2007

Genetic analysis of PROP1 gene in patients with childhood-onset combined pituitary hormone deficiency (CPHD)

Halász Zita , Toke Judit , Patócs Attila , Bertalan Rita , Tömböl Zsófia , Sallai Ágnes , Hosszú Éva , Muzsnai Ágota , Kovács László , Sólyom János , Fekete György , Rácz Károly

Introduction: Combined pituitary hormone deficiency (CPHD) may be associated with mutations of genes coding for pituitary transcription factors, of which the PROP1 and Pit1, gene mutations have been most extensively studied. However, there are controversial data about the prevalence of these gene mutations in non-acquired childhood-onset CPHD patients.Objectives: To examine the prevalence and spectrum of PROP1 and Pit1 gene mutations in CPHD patients a m...