Searchable abstracts of presentations at key conferences in endocrinology

ea0077p183 | Metabolism, Obesity and Diabetes | SFEBES2021

The influence of metabolic states and a high fat meal on circulating chemerin

Murphy Alice , Dumbell Rebecca , Varma Madhu , Helfer Gisela , McTernan Philip

Background: Chemerin is a multifunctional adipokine involved in pathogenesis of metabolic disease by regulating inflammation, adipocyte plasticity and glucose metabolism. It is known to be influenced by age, adiposity and triglycerides, and supports important roles in systemic lipid and glucose metabolism.However, the direct acute effects of circulating chemerin on varying metabolic disease states given a high–saturated fat meal has not been addressed.<p clas...

ea0077op4.3 | Metabolism, Obesity and Diabetes | SFEBES2021

The Chemerin-CMKLR1 Axis is Functionally Important for Central Regulation of Energy Homeostasis

Dumbell Rebecca , Yun Haesung , Maclean Samantha L. , Pors Klaus , Helfer Gisela

Chemerin is a newly discovered chemoattractant adipokine and is a natural ligand for the G protein coupled receptor CMKLR1. Its role in the regulation of energy metabolism and inflammation makes it a promising candidate for urgently needed pharmacological treatment strategies for obesity. To demonstrate a central role of chemerin, we manipulated chemerin signalling in the arcuate nucleus, a specific hypothalamic region associated with appetite regulation. We designed a short-h...

ea0025p116 | Cytokines, growth factors, neuroendocrinology and behaviour | SFEBES2011

Hypothalamic tanycytes express nuclear receptor regulating enzymes in the absence of mRNA transcript

Shearer Kirsty , Stoney Patrick , Ransom Jemma , Helfer Gisela , Ross Sandy , Morgan Peter , McCaffery Peter

Tanycytes line the wall of the third ventricle sitting at the boundary between the cerebral spinal fluid (CSF) and the hypothalamus. Tanycytes actively take up substances from the CSF using their villi-like apical projections that extend into the third ventricle. Retinol is one such compound and can be oxidized by these cells to retinoic acid, which can be released to regulate transcription in the hypothalamus via specific nuclear receptors. Two retinal dehydrogenases (RALDHs)...