Endocrine Abstracts

Endocrine-metabolic alterations such as obesity and metabolic syndrome are closely linked to the development of chronic liver diseases, from metabolic-associated fatty liver (MAFLD) to non-alcoholic steatohepatitis (NASH) and hepatocellular carcinoma (HCC). An emerging hallmark of endocrine-metabolic and hepatic diseases is the appearance or altered expression of pathological splicing variants (SVs). In fact, the components of the cellular machinery involved in the splicing pr...

Obesity is emerging as a prevalent cause of chronic liver damage, which can lead to the development of metabolic-associated fatty liver disease (MAFLD), nonalcoholic steatohepatitis (NASH), or even hepatocellular carcinoma (HCC). Increasing evidence suggests a profound dysregulation of the splicing machinery (spliceosome and splicing factors) in these pathologies; however, the role of PRPF8, a pivotal spliceosome element, has not been described in chronic liver pathologies. Th...