Searchable abstracts of presentations at key conferences in endocrinology

ea0077oc1.1 | Reproductive and Neuroendocrinology | SFEBES2021

Melanocortin-4 receptor agonism improves sexual brain processing in women with low sexual desire

Thurston Layla , Hunjan Tia , Mills Edouard , Wall Matthew , Ertl Natalie , Phylactou Maria , Muzi Beatrice , Patel Bijal , Alexander Emma , Suladze Sofiya , Modi Manish , Eng Pei , Bassett Paul , Abbara Ali , Goldmeier David , Comninos Alexander , Dhillo Waljit

Hypoactive sexual desire disorder (HSDD) is the most prevalent female sexual health complaint worldwide, affecting 1-in-10 women. It is characterised by a persistent lack of desire for sexual activity and sexual fantasies, causing distress or interpersonal difficulties. Treatment options are limited, however, melanocortin-4 receptor (MC4R) agonists have emerged as a promising therapy for HSDD, through unclear mechanisms. Investigating the pathways involved is crucial for our u...

ea0081oc7.2 | Oral Communications 7: Pituitary and Neuroendocrinology 2 | ECE2022

Kisspeptin administration has therapeutic potential for men with low sexual desire by increasing penile tumescence and sexual brain processing

Mills Edouard , Ertl Natalie , Wall Matt B , Thurston Layla , Yang Lisa , Suladze Sofiya , Hunjan Tia , Phylactou Maria , Patel Bijal , Muzi Beatrice , Ettehad Dena , Howard Jonathan , Rabiner Eugenii A , Bech Paul , Abbara Ali , Goldmeier David , Comninos Alexander , Dhillo Waljit

Background: Hypoactive Sexual Desire Disorder (HSDD) is associated with dysfunctional brain activation in regions governing sexual responses, resulting in a deficiency/absence of sexual desire with marked distress. It affects up to 8% of men with detrimental effects on quality of life, interpersonal relationships and fertility, but so far has no licensed treatment options. The reproductive neuropeptide kisspeptin offers a putative therapeutic target owing to its emerging role ...

ea0081p151 | Pituitary and Neuroendocrinology | ECE2022

Sexual brain processing is enhanced by melanocortin-4 receptor agonism

Thurston Layla , Hunjan Tia , Mills Edouard , Wall Matt B , Ertl Natalie , Phylactou Maria , Muzi Beatrice , Patel Bijal , Alexander Emma , Suladze Sofiya , Modi Manish , Eng Pei , Bassett Paul , Abbara Ali , Goldmeier David , Comninos Alexander , Dhillo Waljit

Introduction: Hypoactive sexual desire disorder (HSDD) is characterized by a persistent deficiency of sexual fantasies and desire for sexual activity, causing marked distress or interpersonal difficulty. It is the most prevalent female sexual health problem worldwide, affecting approximately 1 in 10 women, but has limited treatment options despite its substantial health, social, and economic burden. Melanocortin-4 receptor (MC4R) agonists have emerged as a promising therapy fo...

ea0081p445 | Reproductive and Developmental Endocrinology | ECE2022

Kisspeptin improves sexual brain processing in women with low sexual desire

Thurston Layla , Hunjan Tia , Ertl Natalie , B Wall Matt , Mills Edouard , Suladze Sofiya , Patel Bijal , Alexander Emma , Muzi Beatrice , A Rabiner Eugenii , Bech Paul , Goldmeier David , Abbara Ali , Comninos Alexander , Dhillo Waljit

Introduction: Sexual desire is a key component of the sexual response model. Absence or deficiency of sexual desire can lead to marked distress or interpersonal difficulty, termed ‘hypoactive sexual desire disorder’ (HSDD). HSDD is the most common female sexual health complaint worldwide, affecting up to 10% of women. Despite its detrimental impact on psychological well-being and quality of life, treatment options are currently limited. The hormone kisspeptin is a ke...

ea0065p350 | Reproductive Endocrinology and Biology | SFEBES2019

Gonadotrophin rise following the kisspeptin analogue (MVT-602) is increased in women with hypothalamic amenorrhoea compared to healthy women

Eng Pei Chia , Abbara Ali , Phylactou Maria , Clarke Sophie A , Yang Lisa , Mills Edouard , Modi Manish , Papadopoulou Deborah , Plumptre Isabella , Hunjan Tia , Purugganan Kate , Webber Lisa , Salim Rehan , Comninos Alexander N , Dhillo Waljit S

Introduction: Hypothalamic amenorrhoea (HA) is a condition characterised by reduced GnRH pulsatility and is a common cause of anovulatory subfertility. Kisspeptin is an endogenous neuropeptide that regulates hypothalamic GnRH function. Hypothalamic kisspeptin expression is reduced, and kisspeptin receptor expression is increased, in a rodent model of HA. The kisspeptin analogue MVT-602 has a 3-4-fold longer half-life than native kisspeptin-54 (t1/2 0.5 h). We invest...

ea0086oc3.6 | Reproductive and Neuroendocrinology | SFEBES2022

Kisspeptin enhances sexual and attraction brain processing in women with low sexual desire

Thurston Layla , Hunjan Tia , Ertl Natalie , Wall Matthew , Mills Edouard , Suladze Sofiya , Patel Bijal , Alexander Emma , Muzi Beatrice , Bassett Paul , Rabiner Eugenii , Bech Paul , Goldmeier David , Abbara Ali , Comninos Alexander , Dhillo Waljit

Hypoactive sexual desire disorder (HSDD) is a persistent lack of sexual desire, causing marked interpersonal distress. It is the most common global female sexual health problem, although the precise pathophysiology remains uncertain. Existing treatment options are limited by their efficacy and side effects. The neuropeptide kisspeptin offers a potential therapeutic target given its emerging role in modulating reproductive behaviour. Using a combination of psychometric, neuroim...

ea0086op3.1 | Reproductive and Neuroendocrinology | SFEBES2022

Kisspeptin enhances penile tumescence and sexual brain processing in men with low sexual desire

Mills Edouard G , Ertl Natalie , Wall Matt B , Thurston Layla , Yang Lisa , Suladze Sofiya , Hunjan Tia , Phylactou Maria , Patel Bijal , Muzi Beatrice , Ettehad Dena , Bassett Paul A , Howard Jonathan , Rabiner Eugenii A , Bech Paul , Abbara Ali , Goldmeier David , Comninos Alexander N , Dhillo Waljit S

Background: Hypoactive Sexual Desire Disorder (HSDD) is associated with a deficiency of sexual desire with marked distress. It affects up to 8% of men, but has no licensed treatments. The reproductive neuropeptide kisspeptin offers a putative therapeutic target owing to its emerging role in modulating reproductive behaviour in animal models and healthy men. However, there are no studies examining its effects in HSDD. To address this, we performed the first clinical study of ki...