Endocrine Abstracts

Cushing’s disease (CD) is the most common cause of endogenous Cushing’s syndrome in children and adolescents and represents a rare cause of short stature. A 14-year-old boy came to our attention for progressive weight gain and short stature. Birth length and weight were normal; clinical history was negative for use of glucocorticoids. At examination, height was 140 cm (3th centile), weight was 37.7 kg (10th centile). Tanner stage was: G2, PH 3, testis 3 ml. Hypothyro...

Hyperthyroidism associated to hyperthyrotropinemia is a rare condition which can be due to two different causes: resistance to thyroid hormones and TSH secreting adenoma. The differential diagnosis is not easy.We have observed 8 patients with hyperthyroidism associated to inappropriately elevated TSH. All patients had similar basal levels of thyroid hormones and 7 out of 8 had a multinodular goiter.Four out of 8 patients showed lac...

Aim: We compared effectiveness of partial withdrawal of levothyroxine (L-T4) to the use of recombinant human TSH (rhTSH) in preparation for Tg testing. We also evaluated clinical aspects and quality-of-life (QOL) during both regimens.Materials and methods: Ten consecutive patients, previously treated with total thyroidectomy and radioiodine ablation for DTC, underwent rhTSH protocol and, after 15 days, reduced their L-T4 dose by 50% for 5 weeks. At the f...