Searchable abstracts of presentations at key conferences in endocrinology

ea0029p156 | Bone & Osteoporosis | ICEECE2012

Platinum nanoparticle reduces ovariectomy-induced bone loss by decreasing osteoclastogenesis

Kim W. , Kim J. , Kim J. , Choi H.

Platinum nanoparticles have shown to have a remarkable antioxidant activity. Growing evidence between oxidative stress and bone loss suggests that platinum nanoparticle could protect bone loss via modulating oxidative stress. Intragastrical administration of platinum nanoparticle reduced ovariectomy (OVX)-induced bone loss with lowered level of in vivo bone resorption. Platinum nanoparticle inhibited osteoclast (OC) formation via an impaired receptor activator of nuclea...

ea0029p188 | Bone & Osteoporosis | ICEECE2012

Comparison of the effects of hormone replacement therapy on bone mineral density, lipid profiles, and biochemical markers of bone metabolism

Namkung J. , Chung Y. , Kwak S. , Kim J. , Kim M.

Objective: To assess the effects of hormone replacement therapy on bone mineral density (BMD), biochemical markers of bone turnover, and lipid profiles in postmenopausal women.Methods: We retrospectively reviewed the medical records of 199 postmenopausal women who had received care at the Department of Obstetrics and Gynecology of Catholic University Seoul St. Mary’s Hospital between January 1994 and December 2008. The patients were divided into the...

ea0029p1388 | Pituitary Clinical | ICEECE2012

Diabetes insipidus could be the initial sign of primary hypophysitis

Suh S. , Park S. , Joung J. , Cho Y. , Jin S. , Kim S. , Kim H. , Bae J. , Kim J. , Kim S. , Chung J. , Min Y. , Lee M. , Lee M. , Kim K.

Introduction: The natural history of primary hypophysitis is incompletely understood and best treatment remains controversial.Methods: We performed a retrospective study of 19 patients (mean age of 47 years, fifteen women and four men) who were diagnosed with primary hypophysitis in Samsung Medical Center in Seoul, Korea, from January 2001 to October 2011.Results: Two patients had recent pregnancy and underlying autoimmunity. Most ...

ea0029p504 | Diabetes | ICEECE2012

Glycoalbumin is the best indicator for glycemic variability assessed by continuous glucose monitoring

Suh S. , Joung J. , Park S. , Cho Y. , Jin S. , Kim S. , Kim H. , Bae J. , Kim S. , Chung J. , Min Y. , Lee M. , Lee M. , Kim K. , Kim J.

Aims: We investigated the interrelationship between HbA1c, fructosamine, glycoalbumin (GA), 1,5-anhydroglucitol (1,5-AG) with glycemic variability data from continuous glucose monitoring system (CGMS).Methods: Seventy diabetic patients (mean age of 54 years including seven type 1 diabetes mellitus subjects) were enrolled, and all wore a CGMS for 72 hours. For the parameters of glucose excursion, mean glucose, standard deviation (SD) of glucose, the area ...

ea0029p685 | Diabetes | ICEECE2012

A Randomized controlled trial of the effect of internet based mentoring program for type 1 diabetes patients with inadequate glycemic control

Suh S. , Park S. , Cho Y. , Joung J. , Jin S. , Kim S. , Kim H. , Bae J. , Kim S. , Chung J. , Min Y. , Lee M. , Lee M. , Kim K. , Kim J.

Introduction: Widespread availability of internet makes it an attractive communication tool among patients and providers. However, the clinical benefit of telemedical support on diabetes care remains inconclusive. This study is to determine whether an internet based mentoring program can improve glycemic control in type 1 diabetes (T1DM) patients with inadequate glycemic control.Methods: Patients with T1DM on intensive insulin therapy and with HbA1c &#x2...

ea0029p584 | Diabetes | ICEECE2012

Decreased sucrose preference in humans and rodents with diabetes

Yu J , Kim M

Objective: Craving of sweet foods and sucrose may be a big obstacle for glycemic control of diabetic patients. It is generally believed that diabetic patients may prefer sweet taste. However, few studies have examined sucrose preference in diabetic patients. Therefore, we investigated changes in sucrose preference in diabetic condition.Research design and methods: We performed two-alternative staircase methods and forced-choice tracking procedures to ass...

ea0024p28 | (1) | BSPED2010

Properties of a pancreatic side-population stem cell lines from a patient with congenital hyperinsulinism

Sajib A , Kim J , Cosgrove K , Dunne M

NES2Y cells were derived several years ago from a patient following surgery for Congenital Hyperinsulinism (CHI). These cells have the inductive capacity to form insulin-secreting cells, but they are largely uncharacterized. The purpose of this study was to examine the expression and function of the ATP-binding cassette protein ABCG2 and to characterize the cells for their expression of markers of Side Population (SP) progenitor cells and Stellate Cells (SC). Cells were mainta...

ea0029p946 | Female Reproduction | ICEECE2012

Inhibin-α gene promoter polymorphisms in patients with idiopathic premature ovarian failure

Yoon S. , Kim J. , Chae S. , Hwang K. , Choi Y\.

Background: Premature ovarian failure (POF) is a complex disorder defined as the cessation of ovarian function before or at the age of 40. Although the etiology of POF remains unknown in a large proportion of cases, it has been suggested that variations in the Inhibin α gene (INHA) may affect the ovarian function of women. This study was performed to investigate whether the genetic polymorphisms of the INHA gene are associated with idiopathic POF in a Korean population.</...

ea0029p1769 | Thyroid cancer | ICEECE2012

Multiplicity as a prognostic factor of papillary thyroid carcinoma

Kim J. , Won J. , Ko K. , Rhee B.

Backgrounds: Mutiplicity of papillary thyroid carcinoma (PTC) are not an unusual finding, although the origin of these foci is unclear. Either intraglandular metastases from a single dominant tumor or unrelated neoplastic clones were definitively proven as the means by which multicentric PTC form. In addition, there is insufficient clinical information concerning multicentric PTC presentation, prognosis, and long-term follow-up studies after treatment. Multiplicity of PTC has ...

ea0029p157 | Bone &amp; Osteoporosis | ICEECE2012

The level of Osterix expression in osteoblasts is important to prevent IL6-induced inflammatory-prone state

Baek W. , Kim Y. , Park S. , Kwon T. , Park K. , Kim J.

Osterix (Osx) is an essential transcription factor for osteoblast differentiation and bone formation. Osx null mutants died perinatally with a complete absence of bone formation and Osx conditional knockouts in osteoblasts showed the osteopenic phenotype after birth. Even in Osx heterozygous mice with normal bone morphology, the reduced cortical thickness and osteoblast differentiation were observed by QCT and in vitro cell culture, respectively. This result exhibited t...