Searchable abstracts of presentations at key conferences in endocrinology

ea0063ep69 | Diabetes, Obesity and Metabolism | ECE2019

Multiple causes of hyponatremia, which one is the most severe? – case report

Jakubikova Iva , Pelikanova Terezie

Introduction: Hyponatremia is a frequently encountered electrolyte disturbance in clinical practice. The etiology should be searched and revisited properly to be able to guide the appropriate management.Case-report: A 39-years old woman with type 1. diabetes since childhood, after combined pancreas-kidney transplantation with good stable functions of both organs, was admitted to our internal ward for overall fatigue, fever, unspecific abdominal pain with...

ea0056ep76 | Diabetes, Obesity and Metabolism | ECE2018

From severe metformin-associated lactic acidosis to colorectal cancer diagnosis, case-report

Jakubikova Iva , Pelikanova Terezie

Introduction: Metformin is recommended as the first-line pharmacological agent for patients with diabetes mellitus type 2. Its most feared adverse effect is the metformin-associated lactic acidosis (MALA), which appears rarely, but the mortality risk reaches almost 50 percent. This case report describes a story of a severely metformin intoxicated patient with several rare complications and uneven outcome.Case-report: A 74-year-old man was found at home, ...

ea0037ep1088 | Endocrine tumours | ECE2015

Hodgkin's lymphoma presented as goitre: case report

Jakubikova Iva , Cap Jan , Gabalec Filip

Introduction: Lymphomas account for <5% of thyroid malignancies. The vast majority of them are non-Hodgkin’s lymphomas (NHL), especially mucosa-associated lymphoid tissue lymphomas (MALT) and diffuse large B-cell lymphomas (DLBCL). However, Hodgkin’s lymphoma affecting thyroid gland is very rare. Worldwide has been reported <50 cases so far and we describe another one.Case report: A 22-year-old woman was referred to our department of en...

ea0099ep710 | Endocrine-Related Cancer | ECE2024

Car accident leading to an incidental finding of multiple endocrine neoplasia type 1 (MEN-1)

Jakubikova Iva , Hagerf Barbora , Hana Vaclav

Introduction: MEN-1 syndrome is an autosomal dominant disorder caused by mutations in tumor suppressor gene MEN1 and is characterized by the occurrence of parathyroid, pancreatic islet and pituitary tumors. Finding such patient means very pro-active approach to be followed as shows our clinical case.Case-report: A 30-year-old male was sent for an endocrinological investigation due to an incidental finding of a pituitary lesion on a CT scan after a car ac...

ea0041ep315 | Clinical case reports - Pituitary/Adrenal | ECE2016

Posture-responsive primary aldosteronism – the utility of seated saline suppression test

Jakubikova Iva , Horacek Jiri , Spitalnikova Sylvie , Ballon Marek , Lojik Miroslav , Gabalec Filip , Zak Pavel

Introduction: The diagnostic procedure of primary aldosteronism (PA) includes one of four confirmatory tests, of which the saline suppression test (SST) seems to be the most convenient one. Current guidelines recommend SST to be performed in a recumbent position. However, a recent preliminary study demonstrated a higher sensitivity of SST when performed in the upright (i.e. seated) position. Here, we report a case of posture-responsive PA with a negative recumbent SST but clea...

ea0056oc9.3 | Thyroid from basics to clinics | ECE2018

A mouse model of BRAF V600E mutated papillary thyroid cancer imitating sporadic conditions

Jakubikova Iva , Schoultz Elin , Johansson Ellen , Liang Shawn , Patyra Konrad , Kero Jukka , Zak Pavel , Nilsson Mikael

Introduction: Worldwide constantly rising incidence of thyroid cancer promotes research activities. Nowadays the most speculated issue is the clinical significance of BRAF mutation. For sure BRAF mutation is a cancer-specific somatic mutation consistent with papillary thyroid cancer phenotype, otherwise, its role in tumor aggressiveness, progression, and the overall poor outcome is controversial. As far as several clinical studies claim opposing opinions, the learning aspect o...

ea0081p359 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

New insights into obesity treatment provided by smart technologies and telemedicine

Jakubikova Iva , Štolbova Kristyna , Novodvorsky Peter , Dvořakova Iveta , Doležalova Barbora , Kalina Szabolcs , Raška Petr , Kautzner Josef , Haluzik Martin

Introduction: Obesity represents a major public health challenge and is linked with increased risk of multiple medical conditions including atrial fibrillation (AF). We have recently published the study protocol of the ‘The Effect of complex weigHt-reducing interventiOns on rhythm control in oBese subjects wITh Atrial Fibrillation’ (HOBIT-AF) trial. Here we communicate the preliminary results with the focus on the use of smart technologies and telemedicine.<...