Searchable abstracts of presentations at key conferences in endocrinology

ea0081p762 | Late-Breaking | ECE2022

Do polymorphisms of the glucocorticoid and mineralocorticoid receptors play a role in adrenal crises?

Chifu Irina , Janik Freytag , Herterich Sabine , Heike Weber , Hahner Stefanie

Introduction: Polymorphisms of the glucocorticoid (NR3C1) and mineralocorticoid receptor (NR3C2) have been linked to the regulation of HPA-axis and to glucocorticoid sensitivity. We investigated whether NR3C1 and NR3C2 polymorphisms correlate with the occurence of adrenal crises (AC) in patients with primary adrenal insufficiency (PAI).Material and methods: We investigated 100 patients with PAI (70% women, mean age 51±15 years). DNA was extracted fr...

ea0090rc9.3 | Rapid Communications 9: Adrenal and Cardiovascular Endocrinology 2 | ECE2023

Fingerprints of increased susceptibility to adrenal crises in patients with chronic adrenal insufficiency

Chifu Irina , Janik Freytag , Quinkler Marcus , Herterich Sabine , Stephanie Burger-Stritt , Hahner Stefanie

Background: Potentially fatal adrenal crises (AC) still occur in educated patients with adrenal insufficiency (AI). Identifying predisposing factors is necessary for prevention in this patient population.Objectives: Investigating clinical and biochemical fingerprints of increased susceptibility to AC.Material and methods: Our study population included 260 patients with chronic AI, classified as high and low risk according to the fr...