Endocrine Abstracts

Objective: Detecting recurrence of differentiated thyroid cancer is performed by serial measurements of serum thyroglobulin (Tg) levels, however, in the presence of anti-Tg antibodies, this measurement is unreliable. Extracellular vesicles (EVs) are small membrane-enclosed structures, with a prominent role in cell-to-cell communication. All cell types release EVs and they can be isolated from various biofluids, while their cargo reflects the content of the cell of origin. Prev...

Hypercholesterolemia is associated with athero-thrombotic disease, a leading cause of mortality worldwide. Advances in both dietary and pharmacological interventions contribute to prevention and treatment of modifiable risk factors.Purified soybean phytoestrogens, isoflavones genistein (GEN) and daidzein (DAI), were reported to exert moderate cholesterol-lowering effect. In this research first we studied age-related modifications in hepatic cholesterol metabolism and serum est...

Objective: Focal adhesion kinase (FAK) is non-receptor tyrosine kinase that has been shown to affect cell motility, adhesion, invasion, cell survival, proliferation and de-differentiation. Its increased expression has been reported for various types of malignancies and is associated with cancer progression. However, there are less information regarding its posttranslational form, phosphorylated at Tyrosine 397 (pY397-FAK), which represents a key event for complete protein acti...

Objectives: The specter of malignant thyroid lesions comprises tumors with different degrees of differentiation, rendering the differential diagnosis and prognosis of these tumors challenging. Focal adhesion kinase (FAK) is a tyrosine kinase involved in cellular communication and locomotion, functioning as a hub in the interactome of focal adhesions. Its upregulation has been demonstrated in a number of tumor types including thyroid cancer. FAK is regulated on several levels, ...