Searchable abstracts of presentations at key conferences in endocrinology

ea0025p201 | Endocrine tumours and neoplasia | SFEBES2011

Insulinoma presenting as post-prandial hypoglycaemia

Madathil Asgar , Weaver Jolanta

Although insulinoma commonly presents as fasting hypoglycaemia it can rarely present as post prandial hypoglycaemia and even less rarely in association with Type 2 Diabetes Mellitus (T2DM). We describe a case of insulinoma presenting as post-prandial hypoglycaemia and T2DM.A 60 year old man presented with a 6 year history of episodes of double vision and loss of concentration occurring post-prandially. His symptoms were associated with capillary blood gl...

ea0013p242 | Neuroendocrinology and behaviour (including pituitary) | SFEBES2007

Subclinical hypothyroidism is associated with increased cardiovascular risk: A meta-analysis

Razvi Salman , Weaver Jolanta , Pearce Simon

There are discrepancies between different studies with regards to the association of subclinical hypothyroidism (SCH), dyslipidaemia and cardiovascular (CV) disease. Therefore, we have conducted a systematic search and meta-analysis of population-based studies of CV disease in which thyroid status was examined and randomised controlled trials (RCTs) of treatment.The PubMed and Embase databases were searched for relevant studies published between 1976 and...

ea0028oc3.7 | Obesity, thyroid and Addison's disease | SFEBES2012

Subclinical hypothyroidism is associated with fatigue and impaired functional status in males in the Whickham 20-year follow up cohort

Madathil Asgar , Razvi Salman , Vanderpump Mark , Pearce Simon , Weaver Jolanta

Introduction: The association between fatigue, functional status and subclinical hypothyroidism (SCH) remains unclear. The available data is not consistent, and this is likely to be due to selection bias in studies recruiting patients from clinic rather than unselected community populations. Only population surveys looking at prevalence of fatigue and functional status in SCH are likely to provide the answer.Objective and Methodology: We compared the pre...

ea0013p341 | Thyroid | SFEBES2007

The relationship between serum TSH levels and blood pressure in a population sample with normal thyroid function

Razvi Salman , French Joyce , Weaver Jolanta , Vanderpump Mark , Pearce Simon

Background: There is evidence to suggest an association between hypothyroidism (overt and subclinical) and cardiovascular disease. It is unclear whether the set-point of the thyroid axis, within the normal range, may be related to vascular risk.Methods: We have reanalysed the data from the original Whickham study to assess BP in the entire cohort and its relationship to serum TSH within the reference range (0.3–6.0 mIU/L). Multivariate stepwise line...

ea0031oc2.2 | Steroids and thyroid | SFEBES2013

Abnormal cardiac bio-energetics in subclinical hypothyroidism; cardiac magnetic resonance spectroscopic study

Madathil Asgar , Hollingsworth Kieren , Razvi Salman , Blamire Andrew , Taylor Roy , Newton Julia , Weaver Jolanta

Background: It is well established that subclinical hypothyroidism (SCH) is associated with mild ventricular dysfunction and early cardiovascular disease (CVD), but it is unknown if there is an underlying defect in cardiac bio-energetic function.Objective: To quantify the cardiac phosphocreatine/ATP (PCr/ATP) ratio in SCH, compare with healthy controls (HC) and to measure the effect of 6 months of thyroxine treatment.Method: Cardia...

ea0031p355 | Thyroid | SFEBES2013

Levothyroxine therapy affects cerebral blood flow and fatigue in subclinical hypothyroidism

Aslam Nasar , He Jiabao , Madathil Asgar , Razvi Salman , Blamire Andrew , Weaver Jolanta

Background: Overt and subclinical hypothyroidisms are associated with altered cerebral blood flow (CBF) which may be reversed with levothyroxine treatment (T4T). Subclinical hypothyroidism (SCH) is associated with fatigue but it is unclear whether fatigue is related to abnormal CBF and whether T4T has a beneficial impact. We therefore studied fatigued SCH patients before and after T4T and euthyroid non-fatigued healthy controls (HC).Methods: CBF was meas...

ea0025p180 | Endocrine tumours and neoplasia | SFEBES2011

Prevalence of functionality in adrenal incidental masses

Cochrane Jennifer , Rao Preethi , Newby Mike , Handley Graham , Narayanan Kilimangalam , Weaver Jolanta , Razvi Salman

Background: Adrenal incidental masses (incidentalomas) are present in up to 10% of patients. The majority of these adrenal masses are clinically inapparent, but may be functionally active in a significant proportion; thus assessment by endocrinologists is essential.We assessed the functionality of adrenal incidentalomas referred to the endocrinology team at the Queen Elizabeth Hospital in Gateshead.Methods: Patients with adrenal in...

ea0015p396 | Thyroid | SFEBES2008

Subclinical thyroid disorders in ischaemic heart disease: audit of clinical practice within rapid access chest pain clinic

Shakoor Abdul , Blount Emily , Low Melanie , Howe Rachel , Razvi Salman , Barker John , Weaver Jolanta

Introduction: Subclinical hypothyroidism (SCH, higher serum thyroid stimulating hormone (TSH) with normal thyroid hormone) is associated with an increased risk of ischaemic heart disease (IHD). Subclinical thyrotoxicosis (SCT, lower serum TSH with normal thyroid hormone) is also associated with an increased risk of atrial fibrillation, cardiovascular morbidity and mortality.Aim and methods: To examine the relationship between IHD and thyroid disorders in...

ea0015oc35 | Thyroid | SFEBES2008

Circulating endothelial progenitor cells are reduced in subclinical and overt hypothyroidism

Shakoor Abdul , Aldibbiat Ali , Ingoe Lorna , Campbell Susan , Sibal Latika , Isaacs John , Shaw James , Home Philip , Weaver Jolanta

Introduction: Subclinical hypothyroidism (SCH) is recognised as an increased risk for cardiovascular disease (CVD). Low number of circulating endothelial progenitor cells (EPC), defined as mononuclear cells, expressing endothelial (vascular endothelial growth factor receptor, VEGFR-2) and stem cell (CD-34, CD-133) markers is associated with CVD. Our aim was to identify whether reduced EPC number might contribute to increased CV risk in subclinical and overt hypothyroidism (Hy)...

ea0031p318 | Steroids | SFEBES2013

Novel loci for familial autoimmune Addison's disease detected by linkage analysis

Mitchell Anna L , Boe Wolff Anette , Gan Earn H , MacArthur Katie , Erichsen Martina M , Weaver Jolanta U , Vaidya Bijay , Bensing Sophie , Husebye Eystein , Cordell Heather J , Pearce Simon H S

Due to the rarity of autoimmune Addison’s disease (AAD), it has proved difficult to gather large case cohorts for genetic studies. Linkage analysis offers a powerful means of identifying genetic susceptibility loci but has never been applied to AAD because of the scarcity of families containing ≥2 affected individuals. We collected DNA from 23 such families to perform the first linkage study in AAD.We genotyped 117 samples (50 cases, 67 contro...