Searchable abstracts of presentations at key conferences in endocrinology

ea0011p714 | Reproduction | ECE2006

Efficacy of Testogel in the treatment of hypogonadism in routine clinical practice

Jones TH , Chilukuri LR , Munir A

Introduction: Testogel is now established treatment for male hypogonadism. The aim of TRT is to resolve hypogonadal symptoms and achieve physiological levels of testosterone.Objective: To determine the efficacy of Testogel 50 mg/day, in achieving symptomatic benefit and physiological testosterone level in 100 male patients.Method: Retrospective review of 100 case notes from the andrology clinic. Men included were between 16 and 80 ...

ea0019p99 | Clinical practice/governance and case reports | SFEBES2009

Testosterone replacement therapy in Prader-Willi syndrome with diabetes markedly improves glycaemic control

Muraleedharan V , Rolfe C , Jones TH

Prader-Willi syndrome is characterized by severe hypotonia and feeding difficulties in early infancy, followed in later infancy or early childhood by excessive eating and gradual development of morbid obesity and learning difficulties. Hypogonadism occurs in both males and females, manifested by genital hypoplasia, incomplete pubertal development, and infertility. Type 2 diabetes mellitus is common in obese individuals, most likely secondary to hyperphagia. Diabetes is often d...

ea0019p329 | Steroids | SFEBES2009

Testosterone deficiency in the testicular feminised mouse model is significantly associated with the development of liver steatosis: a mechanism that is independent of the androgen receptor

Dugdale C , Nettleship J , Jones TH

To determine the role of testosterone on liver fat deposition using the testicular feminised mouse (Tfm) model. The Tfm does not have a functional androgen receptor (AR) and low circulating levels of testosterone due to associated 17╬▒hydroxylase deficiency.Liver tissue was obtained after 24 weeks of feeding with a cholesterol enriched diet from the following groups: (1) XY placebo-treated (littermate control), (2) Tfm placebo, (3) XY castrate placeb...

ea0011p936 | Thyroid | ECE2006

Hyperthyroidism presenting as ventricular fibrillation

Chilukuri LR , Merza Z , Jones TH

A 42-year-old lady, previously fit and well, presented to the Accident and Emergency department following a cardiac arrest. She had received four D.C. shocks by the ambulance crew prior to cardioversion to sinus rhythm from ventricular fibrillation. She was admitted to ITU and during this admission developed a grandmal seizure. Physical examination was unremarkable and CT scan of her head was normal. Blood tests including full blood count and biochemistry were all normal excep...

ea0014p57 | (1) | ECE2007

Effect of testosterone replacement therapy on adipocytokines in hypogonadal men with Type 2 diabetes

Kapoor D , Clarke S , Stanworth R , Channer KS , Jones TH

Serum testosterone level is known to inversely correlate with insulin sensitivity and obesity in men. Furthermore, there is evidence to suggest that testosterone replacement therapy reduces insulin resistance and visceral adiposity in Type 2 diabetic men. Adipocytokines are hormones secreted by adipose tissue and contribute to insulin resistance. We report a double-blind placebo controlled crossover study in 20 hypogonadal Type 2 diabetic men examining the effect of testostero...

ea0014p57 (1) | (1) | ECE2007

Effect of testosterone replacement therapy on adipocytokines in hypogonadal men with Type 2 diabetes

Kapoor D , Clarke S , Stanworth R , Channer KS , Jones TH

Serum testosterone level is known to inversely correlate with insulin sensitivity and obesity in men. Furthermore, there is evidence to suggest that testosterone replacement therapy reduces insulin resistance and visceral adiposity in Type 2 diabetic men. Adipocytokines are hormones secreted by adipose tissue and contribute to insulin resistance. We report a double-blind placebo controlled crossover study in 20 hypogonadal Type 2 diabetic men examining the effect of testostero...

ea0011p349 | Diabetes, metabolism and cardiovascular | ECE2006

Physiological concentrations of testosterone inhibit extracellular calcium entry via voltage-gated calcium channels in the A7r5 vascular smooth muscle cell line - a non-genomic effect

Hall J , Jones RD , Channer KS , Peers C , Jones TH

Testosterone (T) acts as a coronary vasodilator and reduces myocardial ischemia in men with coronary heart disease. We have previously demonstrated that T inhibits the pore forming alpha1c subunit of the cardiovascular L-type calcium channel in HEK293 cells. In this study we investigated the effects of T and 5╬▓-dihydrotestosterone (5╬▓-DHT) on extracellular calcium entry in A7r5 vascular smooth muscle cells (VSMCs). A7r5 cells grown on coverslips in 12-well plates in ...

ea0011p358 | Diabetes, metabolism and cardiovascular | ECE2006

The vasodilatory action of oestrogen in isolated human pulmonary arteries

Smith AM , Sandher RK , Jones RD , Jones TH , Channer KS

Background: This study was carried out to assess the vasodilatory effect of oestrogen in the human pulmonary circulation. The influence of gender upon the response to oestrogen was also assessed.Method: Isolated human pulmonary arteries were studied by wire myography. Vessels were obtained from male (n=6, age 70±9 years) and female (n=6, age 59±9 years) patients. The study was approved by the local ethics committee. Vessels were p...

ea0011p392 | Diabetes, metabolism and cardiovascular | ECE2006

Testosterone replacement therapy reduces insulin resistance, and improves glycaemic control in hypogonadal men with Type 2 diabetes

Kapoor D , Goodwin E , Channer KS , Jones TH

Type 2 diabetes mellitus is associated with increased prevalence of low serum testosterone levels in men [1]. Testosterone levels in men are known to be positively correlated with insulin sensitivity and negatively with visceral obesity. We performed a double blind placebo controlled crossover study to determine the effect of testosterone treatment on insulin resistance and glycaemic control in 24 hypogonadal men (10 patients treated with insulin) above age of 30 with Type 2 d...

ea0011p403 | Diabetes, metabolism and cardiovascular | ECE2006

Low endogenous testosterone induces fatty streak formation following cholesterol feeding in the testosterone deficient testicular feminised mouse and castrated male

Nettleship JE , Jones RD , Biggins CM , Channer KS , Jones TH

Low endogenous testosterone is associated with atherosclerosis in elderly men. The aim of this study was to examine the role of the androgen receptor (AR) in the development of atherosclerosis and determine whether an inactive AR coupled with testosterone deficiency, inherent to the testicular feminised (Tfm) mouse, is associated with atherosclerosis following cholesterol feeding compared to surgically-castrated male littermates with AR intact.Ten-week-o...