Searchable abstracts of presentations at key conferences in endocrinology

ea0016p360 | Growth and development | ECE2008

Study of dimer and oligomers of human growth hormone

Junnila Riia , Wu Zida , Strasburger Christian

There is a high heterogeneity of human growth hormone (hGH), variation rising from the different genes in pituitary and placenta, alternative splicing, post-translational modifications, oligomerization and binding to the growth hormone binding protein (GHBP). Distinguishing between different variants remains problematic and there is still quite little information about the proportion of these variants in circulation of both healthy individuals and of patients with growth hormo...

ea0020p534 | Growth and Developmental Endocrinology | ECE2009

Characterization of growth hormone (GH) mutants R77C and D112G found in patients with retarded growth

Junnila Riia , Braig Friederike , Piilonen Katri , Strasburger Christian , Wu Zida

Introduction: Two heterozygous missense mutations R77C and D112G have been identified in GH-1 gene of patients with short stature by Takahashi et al. These patients had high serum immunoreactive GH concentrations but low IGF-1 concentrations, indicating bioinactivity of their GH. Separation of GH in patientsÂ’ serum by isoelectric focusing revealed the coexistence of mutant and wild type (wt) GH. In order to understand the molecular mechanism of the isolated GH defi...