Searchable abstracts of presentations at key conferences in endocrinology

ea0012p22 | Clinical case reports/Governance | SFE2006

Management of occult virilizing ovarian tumours in postmenopausal women

Ashawesh KA , Fernando KA , Redford DH , Barton D

BackgroundIn postmenopausal women, rapidly progressive hirsuitism or virilization raises the suspicion of an androgen-secreting tumor. Adrenal tumours are usually ruled out by hormonal testing and imaging studies. Small virilizing ovarian tumours may not be detectable by imaging studies.CaseA 61-year-old woman presented with hirsutism and male-pattern baldness developing over a two year period. 40 years previ...

ea0075d16 | Diabetes | EYES2021

Hyperosmolar hyperglycaemic state (HHS) in type 1 and type 2 diabetes induced by asymptomatic SARS-CoV-2 infection: 2 case reports

Kumar Mohit , Chu Ka Wing

HHS is a rare hyperglycaemic emergency, typically precipitated by infection in people with T2DM. There are few recorded cases of COVID induced pure HHS. We here by report 2 further cases, including the first known reported case in a person with T1DM.Case 1: 81yo male with T1DM (on glargine and aspart insulin, HbA1c 57 mmol/mol) presentedwith lethargy, general deterioration and a fall.Therewere no new symptoms offever/cough/breathlessness or change in tas...

ea0012p90 | Pituitary | SFE2006

Cabergoline is an effective and well tolerated primary and adjunctive treatment for acromegaly

Moyes VJ , Metcalfe KA , Drake WM

Cabergoline is a dopamine agonist that may be used as primary or adjunctive therapy for acromegaly. Although one study suggested biochemical control may be achieved in a substantial proportion of patients (Abs et al, JCEM 1998), it is still commonly perceived to be a relatively ineffective treatment, possibly on account of inadequate dosing.We performed a retrospective case notes review of 9 consecutive acromegalic patients to determine the effectiveness...

ea0012p111 | Reproduction | SFE2006

Endocrine evaluation of gynaecomastia

Ashawesh KA , Chakrabarty A , Usman T , Barton D

BackgroundThe role of endocrine testing in idiopathic gynecomastia is controversial. Previous studies suggested that such testing is rarely productive and best done selectively.ObjectivesA retrospective study was performed to evaluate the usefulness of a routine endocrine testing in patients presenting with gynecomastia.MethodsThe medical records of 71 patients wi...

ea0008p19 | Cytokines and growth factors | SFE2004

Age is an important determinant of the growth hormone response to sprint exercise in young men

Stokes KA , Nevill ME , Hall GM

Exercise is a potent stimulus for growth hormone (GH) release and a single 30 s sprint elicits a marked increase in circulating GH. However, the mechanisms regulating GH release during and after exercise are not fully understood (1). The aim of the present study was to determine whether age, body composition, the metabolic response to or performance during a single 30 s sprint are predictors of the GH response in young men.Following local Ethics Committe...

ea0086op4.4 | Metabolism, Obesity and Diabetes | SFEBES2022

iPSC-derived hepatocytes as a novel tool for glycogen storage disease 1A (GSD1A) modelling and drug screening

Nikolaou Nikolaos , Aksoy Melissa , Cheung Ka , Chung Samuel , Heslop James , Gil Carlos , Panman Lia

Glycogen storage disease 1A (GSD1A) is an inherited metabolic disorder caused by glucose-6-phosphatase (G6PC) deficiency. Patients with GSD1A present disturbed glucose homeostasis and exhibit glycogen accumulation accompanied by hepatomegaly, hypoglycemia, lactic acidosis and hyperlipidemia. However, there are currently no licensed treatments for GSD1A, and human in vitro systems for disease modelling and drug screening are lacking. We aimed to develop a human hepatoc...

ea0086p225 | Metabolism, Obesity and Diabetes | SFEBES2022

Characterisation of the mechanism of long-chain fatty acid uptake in human-derived pancreatic beta cells

Clavelo-Farrow C , Leslie KA , Fletcher M , Docherty FM , Akerman I , Gallagher MT , Thomas P

Background: It is widely believed that increased circulatory concentrations of long-chain saturated fatty acids (LC-SFA) significantly contribute to the death and dysfunction of pancreatic β-cells in the development of type 2 diabetes (T2D). The mechanism by which LC-SFA cross the β-cell plasma membrane has not been fully established. This work aims to characterise the mechanism underpinning this uptake. Ultimately, regulation of LC-SFA entry may maintain β-cell...

ea0090ep260 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

Relation of HLA system genes in patients with type 1 diabetes and other autoimmune diseases

Lekić Ivan , Marušić Romana , Marczi Saška , Bačun Tatjana

Background: Type 1 diabetes mellitus (T1DM) is caused by destruction of pancreatic beta cells. Children and adolescents with type 1 diabetes have an increased risk of developing other autoimmune diseases, most commonly autoimmune thyroiditis and celiac disease.Objectives: To examine the frequency of individual human leukocyte antigen (HLA) alleles in people with T1DM and associated autoimmune (AI) diseases of the thyroid, digestive system, and skin, and ...

ea0041ep453 | Diabetes (to include epidemiology, pathophysiology) | ECE2016

Frequency of diabetes and thyroid autoantibodies in patients with type 1 diabetes and their siblings

Kim Chan Jong , Oh Ka Young , Kim Yun Hee , Yang Eun Mi

Background: We investigated the frequency of autoimmune thyroid and diabetes antibodies in patients with type 1 diabetes mellitus (T1DM), their siblings, and controls.Methods: Glutamic acid decarboxylase antibodies (GADA), islet cell antibodies (ICA), insulin autoantibodies (IAA), and thyroid antibodies were identified in all subjects.Results: The rates of positive GADA and IAA were significantly higher in probands compared to sibl...

ea0041ep699 | Growth hormone IGF axis - basic | ECE2016

A placebo-controlled study of repeated subcutaneous doses of COR-005 alone or with octreotide on GHRH-stimulated GH and pharmacokinetics in healthy male subjects

Kutz Klaus , Haschke Manuel , Beglinger Christoph , Liška Jiři , Dehning Carsten , Cohen Fredric

Octreotide is first-line medical therapy for patients with acromegaly. Up to 80% of patients are not satisfactorily controlled on octreotide alone and up to 20% have no response. COR-005 (previously DG3173) is a novel somatostatin analogue under investigation for treatment of acromegaly. COR-005 has high affinity for human somatostatin receptor subtypes 2, 4 and 5.The study was designed to assess pharmacokinetics of escalating doses COR-005 sc tid and co...