Searchable abstracts of presentations at key conferences in endocrinology

ea0090p723 | Reproductive and Developmental Endocrinology | ECE2023

Early markers of metabolic disorders, such as leucin and isoleucine level and lipid accumulation product, should be considered as the potential additional criterium in PCOS classification

Paczkowska Katarzyna , Rachoń Dominik , Berg Andrzej , Rybka Jacek , Kapczyńska Katarzyna , Bolanowski Marek , Daroszewski Jacek

Background: Polycystic ovary syndrome (PCOS) is a common endocrine disorder that affects reproductive age women and predispose to the development of metabolic disturbances. However, Rotterdam criteria, commonly used to diagnose and classify this disorder, do not include metabolic markers. Recent research has shown that several metabolic factors may play a role in PCOS pathogenesis. Branched-chain amino acids (BCAA) are the group of essential amino acids including leucine, isol...

ea0099p564 | Thyroid | ECE2024

Pathogenic variants of CHEK2 gene in thyroid cancer (TC) patients with a personal and/or familial history of other malignancies

Kapusta Dominika , Domagała Bartosz , Kapczyński Norbert , Kachnic Marek , Nogieć Anna , Trofimiuk-Muldner Malgorzata , Hubalewska-Dydejczyk Alicja

CHEK2, located on chromosome 22q, is a tumor suppressor gene. ItsÂ’ pathogenic variants are often associated with a tumor predisposition syndrome 4, with an increased risk of breast, prostate and colorectal cancers. There are some reports of an increased risk of papillary thyroid cancer (PTC) in carriers of the CHEK2 pathogenic variants. Current guidelines, however, do not recommend general screening of TC patients. The study assessed the prevalence of pa...