Endocrine Abstracts

There are more registered Independent Nurse Prescribers than ever before, and with the advent of paediatric specific prescribing courses and more advanced clinical practice degrees, these numbers will certainly increase. The advantages of practising as an independent nurse prescriber can benefit patient care, improve patient safety, and enhance the overall quality of care a patient receives. This presentation will explore these concepts and introduce advanced clinical skills i...

This session will focus on spermatogenesis and pubertal development in boys, emphasizing the use of the Tanner staging system in clinical practice. Implications of early and delayed puberty will be discussed, plus normal pubertal development, and its relevance in sperm banking for children undergoing cancer treatment....

Abstract unavailable....

The population of follicles within the mammalian ovary declines steadily with age. The majority of follicles in the ovary are at the primordial (resting) stage of development, each consisting of a small oocyte surrounded by a single layer of flattened granulosa cells (GCs). The rate at which follicles enter the growing phase, involving oocyte growth and GC shape change and proliferation, is a major determinant of the rate at which the reserve of primordial follicles is deplete...

Epigenetic mechanisms are gaining increasing interest in oncology, both as drivers of tumourigenesis and as potential novel therapeutic targets. This is particularly relevant in neuroendocrine neoplasms (NENs), as a key tumour suppressor gene involved in NEN development, multiple endocrine neoplasia type 1 (MEN1), plays a critical role in epigenetic regulation of gene expression through micro RNA (miRNA) and histone modification pathways. MEN1 mutations can g...

Background: There are a variety of growth hormone delivery devices (GHDD) available to children requiring growth hormone (GH) therapy. Many paediatric endocrine nurses can offer patients and their families a choice of the products that are available, which can sometimes be overwhelming. However, factors such a licenced clinical indications have to be considered, as well as cost. This study explored nurses viewpoints on GHDD.Aim: The purpose of this proje...

Pancreatic neuroendocrine tumours (PNETs) are increasing in incidence, and have a 5-year survival rate of <50%. This is largely because, despite recent advances, current treatments are often ineffective, and therefore additional therapeutic agents are required. Epigenetic inhibitors may offer a novel class of anti-cancer drugs, as PNETs harbour mutations of chromatin remodelling genes including ATRX and DAXX, while menin, encoded by MEN1, interac...

The Endocrine service is predominantly out-patient based looking after a range of conditions with strong dependence on biochemical monitoring for clinical safety. Due to capacity demands we needed to explore the options available to facilitate safe monitoring with potential to increase capacity.The development of an IT based system allowed for the capacity increase, provided prompt communication with GP’s, improved patient safety, included a diagnos...

This case study presentation formed the summative assessment aspect of “The principles of care for the child and young person in Endocrinology” module at London Southbank University. Hyperinsulinaemic Hypoglycaemia (HH), is characterised by the inappropriate secretion of insulin from the pancreatic β-cells in relation to the blood glucose concentration, and is the most common cause of severe and persistent hypoglycaemia in infancy and childhood. Approximately on...

Background: The incidence of gestational diabetes appears to be rising, likely related to the increasing prevalence of overweight/obesity in the general population, and the trend of increasing maternal age. However, it must be remembered that some women newly diagnosed with diabetes in pregnancy have latent type 1 diabetes; GAD (glutamic acid decarboxylase) antibody measurement may be useful in cases with atypical features. We present two such cases.Case...