Searchable abstracts of presentations at key conferences in endocrinology

ea0073pep3.3 | Presented ePosters 3: Pituitary and Neuroendocrinology | ECE2021

Insulinoma-associated protein 1 (INSM1) may serve as a sensitive and specific immunohistochemical and molecular biomarker of neuroendocrine differentiation in pancreatic neuroendocrine tumors (PNETs)

Katalinic Darko , Aleric Ivan , Vcev Aleksandar , Kattner Elke

IntroductionInsulinoma-associated-1 (INSM1), encoded by the INSM1 gene is key factor in pancreatic endocrine, sympatho-adrenal and pan-neurogenic development. It has also been identified in multiple tumors of neuroendocrine origin but not thoroughly investigated as a potential neoplastic biomarker. The aim of the study was to evaluated INSM1 as a semiquantitative immunohistochemical biomarker as well as quantitative reverse transcriptase polymer...

ea0070aep731 | Pituitary and Neuroendocrinology | ECE2020

The expression of oxytocin receptor (OXTR) in metastatic pancreatic neuroendocrine tumors (PNETs)

Katalinic Darko , Bildat Stephan , Kattner Elke , Soerensen Lilly , Aleric Ivan , Vcev Aleksandar

Introduction: Pancreatic neuroendocrine tumors (PNETs) are rare malignant neoplasms which incidence is continually increasing. They are characterized by diverse biological behaviour and impact on the patients’ prognosis, ranging from clinicaly indolent to very aggressive. Oxytocin receptor (OXTR) is a member of the family of G-protein receptors and is present on the cell-surface of the gastrointestinal organs. Unfortunately, theimpact of OXTR signaling on the development...