Searchable abstracts of presentations at key conferences in endocrinology

ea0029p559 | Diabetes | ICEECE2012

Low testosterone is associated with decreased expression of glut-4 and hexokinase 2 in muscle of the testicular feminised mouse

McLaren D , Kelly D , Akhtar S , Channer K , Jones T

Testosterone deficiency is a common in men with type two diabetes (T2D). We have shown testosterone replacement therapy (TRT) improves insulin resistance and glycaemic control. The mechanisms by which testosterone mediates this action are unknown but may be due to a combination of effects on muscle, liver and adipose tissues. This study investigates the expression of Glut4 and HK2, (two key proteins involved in insulin sensitivity) in muscle tissue of the testicular feminised ...

ea0029p269 | Cardiovascular Endocrinology and Lipid Metabolism | ICEECE2012

Testosterone replacement therapy inhibits key enzymes of fatty acid synthesis in mouse liver

Brooke J. , Kelly D. , Akhtar S. , Muraleedharan V. , Jones T.

Fatty liver (Hepatic Steatosis) is common in men with type 2 diabetes mellitus (T2DM). Furthermore there is a high prevalence of testosterone deficiency (up to 40%) in this population. Testosterone replacement therapy (TRT) has been shown to reduce elevated serum liver transaminase levels in hypogonadal men. The testicular feminised (Tfm) mouse exhibits a non-functional androgen receptor (AR) and low circulating testosterone levels. We have previously shown that a high-fat die...

ea0029p270 | Cardiovascular Endocrinology and Lipid Metabolism | ICEECE2012

Effect of testosterone on hepatic liver X receptor and ApoE expression as a potential mechanism of atheroprotection in the testicular feminised mouse

Kelly D. , Akhtar S. , Brooke J. , Channer K. , Jones T.

Testosterone deficiency is associated with several cardiovascular risk factors. Testosterone replacement therapy (TRT) improves insulin sensitivity, inflammation and cholesterol. Liver X receptor (LXR) is a nuclear receptor which regulates lipid and glucose metabolism, stimulates cholesterol efflux and ApoE, and suppresses inflammation. LXR agonists cause hepatic steatosis but protect against atherosclerosis. TRT attenuates high-cholesterol diet-induced hepatic steatosis in th...