Endocrine Abstracts

SIMBA (Simulation via Instant Messaging- Birmingham Advance) is a novel pedagogical simulation-based learning model which improves clinicians’ confidence in managing conditions in endocrinology and diabetes. More than 25 SIMBA sessions have been conducted between May 2020 and August 2022. Each session included 4 to 6 real-life anonymised case scenarios followed by an interactive discussion. SIMBA effectively adopts Kolb’s theory to provide the best possible experienc...

Background: Pembrolizumab is a novel anti-cancer drug that targets programmed cell death protein 1 (PD-1) receptor on lymphocytes resulting in their activation against tumor cells. PD-1 receptors are also distributed in endocrine organs and pembrolizumab use has long-been associated with hypophysitis and thyroiditis. We describe a patient with pembrolizumab-induced thyroiditis who developed an uncommon fulminant Type 1 Diabetes Mellitus (FT1D).Case prese...

A 61-year-old man presented to his primary care service with complains of frequent hot flushes, dizziness and headache. Following initial screening, an incidental pituitary lesion was diagnosed on computed tomography (CT) scan and hence was referred to specialist review. Further detailed history revealed similar presentation with dizziness and hot flushes two and a half years ago. He was then diagnosed with essential hypertension after a negative work-up for Cushing disease. H...

Background: Insulinoma is the most common cause of hypoglycaemia due to endogenous hyperinsulinemia. However, they can sometimes present with atypical features. Some of the patients can also develop serious adverse effects to medical treatment. We present a case with atypical features and further developed serious adverse effects with medical treatment for insulinoma.Case presentation: A 42-year-old Caucasian female presented with recurr...

Case Presentation: 37-year-old woman of South Asian origin was referred from retinopathy screening to our diabetes clinic for evaluation of an unusual finding during her retinal screen. Her retinal blood vessels appeared white in contrast to normal pink to red colour. She was recently diagnosed with type 2 diabetes and with type 1 hyperlipidaemia (T1 HPLA) confirmed by genotype for more than 10 years for which she had suboptimal control with multiple hospitalisations with recu...

A 22-year-old Caucasian female was referred to thyroid specialist clinic due to difficulties fully suppressing her thyroid stimulating hormone (TSH) despite high dose combination therapy of triiodothyronine (T3) and thyroxine (T4) treatment. She had a well-differentiated thyroid -carcinoma of left thyroid lobe treated with left lobectomy. Several other small primary thyroid carcinoma lesions were detected on further examination of the histology which lead to completion thyroid...

Background: September is celebrated as PCOS awareness month worldwide and is aimed at improving the lives of those with PCOS, promoting research, and strengthening advocacy efforts. While significant financial and human resources are invested in promotions during this month, to the best of our knowledge, there is no evidence to show the impact of this initiative. In our study, we evaluated the global digital impact of PCOS Awareness Month, tracking commonly used hashtags as su...

Background: Although pheochromocytoma classically presents with headaches, palpitations and paroxysmal hypertension, uncommon presentations such as cardiomyopathy, stroke and subarachnoid haemorrhage have been documented. We present one such infrequent presentation of myocardial infarction with normal coronary arteries (MINOCA).Case presentation: A 79-year Caucasian female presented with central crushing chest pain radiating to left arm associated with h...

Aims: To assess the incidence of Ipilimumab associated hypophysitis and its common presentations.Methods: All patients who developed Ipilimumab induced hypophysitis following treatment for Malignant melanoma at a large tertiary care centre in West Midlands, United Kingdom from 2012 to 2014 were included in the study. Patients with known pituitary disease prior to treatment and/or received other systemic immunotherapy following Ipilimumab treatment were e...

Context: Polycystic ovarian syndrome (PCOS) is the most common endocrine disorder in women of classic androgen synthesis. Recent work has highlighted that impaired DHEA sulfation results in enhanced androgen production. Here, we evaluated the relationship between DHEA and DHEAS and androgen excess and metabolic phenotype in PCOS.Patients and methods: We compared 65 women with PCOS to 35 healthy women matched for age and body mass index (BMI). All subject...