Searchable abstracts of presentations at key conferences in endocrinology

ea0029oc15.2 | Thyroid Basic | ICEECE2012

Ligand bound-thyroid hormone receptor contributes to reprogramming of pancreatic exocrine cells to insulin-producing cells via induction of Ngn3 and MafA

Furuya F. , Shimura H. , Endo T. , Kobayashi T.

Introduction: One goal of diabetic regenerative medicine is to instructively convert mature pancreatic exocrine cells into insulin-producing cells. We recently reported that liganded thyroid hormone receptor α (TRα) plays a critical role in expansion of the β-cell mass during postnatal development.Materials and Methods: AdTRα is a recombinant adenoviral vector that expresses human TRα1 under the control of the cytomegalovirus pro...

ea0029p687 | Diabetes | ICEECE2012

DPP-4 inhibitor vildagliptin reduces urinary albumin excretion in type 2 diabetic patients with microalbuminuria

Watanabe M. , Furuya F. , Kobayashi T.

Introduction: A potent and selective DPP-4 inhibitor improves islet function by enhancing α- and β-cell responsiveness to glucose in the diabetic patients. Renal impairment is a common complication of type 2 diabetes mellitus (T2DM). Vildagliptin is used to treat T2DM as monotherapy or in combination with other antidiabetic drugs, since that it efficiently decreases glycated hemoglobin (HbA1c) values. Additionally, vildagliptin has been shown to be safe in patients w...

ea0029p644 | Diabetes | ICEECE2012

Association of cardio-ankle vascular index with diabetes mellitus-related peripheral arterial disease in chronic hemodialysis patients

Okamura A , Furuya F , Akiyama D , Shimura H , Motosugi A , Haraguchi K , Kobayashi T

Introduction: Peripheral arterial disease (PAD) is increased associated with an accumulation of patients with end stage kidney disease and diabetes. Recently, the cardio-ankle vascular index (CAVI) has been developed as an index reflecting the stiffness of the aorta independently of blood pressure. The aim of this study was to assess the prevalence of PAD in hemodialysis patients with diabetes.Methods: To examine the usefulness of CAVI to screen for the ...