Searchable abstracts of presentations at key conferences in endocrinology

ea0062p65 | Poster Presentations | EU2019

Pituitary abscess with meningitis: a rare presentation

Kochhar Rupinder , Naseem Asma , Kearney Tara

Case history: A 42-year-old lady was referred from neurology clinic after being assessed for symptoms of headaches, dizziness, transient visual problems and paraesthesia over her limbs for 2 months. On review, she complained of amenorrhoea and was noted to be pale, however, her neurological examination including visual fields to confrontation and ocular movements were normal. Subsequent investigations were consistent with pan-hypopituitarism and she was promptly commenced on h...

ea0065p28 | Adrenal and Cardiovascular | SFEBES2019

Recalibration of thinking about adrenocortical function assessment: How the random cortisol relates to the short Synacthen test ‘Verdict’

Michaelidou Maria , Yadegarfar Ghasem , Robinson Adam , Naseem Asma , Khan Inamullah , Kochhar Rupinder , Scargill Jonathan , Trainer Peter , Heald Adrian

Background: The short synacthen test (SST) is the most commonly performed investigation to assess for suspected adrenocortical dysfunction. We investigated how random cortisol levels may relate to pass/fail on the STT.Methods: We analysed the relation between random cortisol measurements taken between 04.40 and 20.52 in the day and results of SST baseline and 30/60 min cortisol performed over a 12 month period (338 SSTs) at Salford Royal Hospital. Serum ...

ea0065p189 | Metabolism and Obesity | SFEBES2019

The FreeStyle libre flash glucose monitoring system: how it has improved glycaemic control for people with type 1 diabetes (T1DM) in Eastern Cheshire, UK

Dwived Shivangi , Heald Adrian , Naseem Asma , Kochhar Rupinder , Khan Inamullah , Leivesley Kate , Metters Ann , Horne Linda , Steele Tom

Introduction: Many people with type 1 diabetes continue to experience suboptimal glycaemic control. We now also know that often HbA1c levels are an inaccurate reflection of glycaemic patterns and variability. We describe here how the systematic use of the FreeStyle Libre flash monitor helped improve the glycaemic control of many people with type 1 diabetes.Methods: We report the outcomes of 92 consecutive adults (18 years of age or more) with type 1 diab...

ea0065p412 | Thyroid | SFEBES2019

Health utility of people with treatment-resistant hypothyroidism as measured with the EQ-5D-5L quality of life questionnaire

Hughes Dyfrig , Townson Julia , Owen-Jones Eleri , Playle Rebecca , Khan Inamullah , Kochhar Rupinder , Naseem Asma , Heald Adrian

Background: Primary hypothyroidism affects about 3% of the general population (5.1% women and 0.9% men). The majority of people are treated adequately with levothyroxine. However about 5–10% of hypothyroid patients (representing between 75 000 and 150 000 adults in the UK) continue to experience profound and sometimes disabling symptoms, such as fatigue/depression/impaired cognition, in spite of being adequately replaced biochemically. Before any trial of alternatives to ...

ea0065p190 | Metabolism and Obesity | SFEBES2019

Androgen receptor reduced sensitivity is associated with increased mortality, poor glycemic control and BMI in men with type 2 diabetes – a 14-year follow up study

Heald Adrian , Yadegarfar Ghasem , Livingston Mark , Fachim Helene , Lunt Mark , Narayanan Ram Prakash , Siddals Kirk , Cortes Gabriela , Hackett Geoff , Naseem Asma , Kochhar Rupinder , Inamullah Khan , Donn Rachelle , Gibson Martin , Jones Hugh

Introduction: Hypogonadism is associated with poorer glycaemic outcomes/increased all cause and cardiovascular morbidity/mortality in type 2 diabetes mellitus (T2DM). Increasing CAG repeat number within exon 1 of the androgen receptor gene is associated with increased androgen receptor resistance/insulin resistance. We here investigated the link between CAG repeat number and outcomes in T2DM men.Methods: We determined in a long-term 14-year follow-up coh...