Endocrine Abstracts

Type 2 diabetes (T2D) is a multi factorial disease with increased prevalence globally. The risk of developing T2D is determined by the interaction of genetic and environmental factors. Over the decades of research, hundreds of T2D genetic susceptibility markers (mostly single nucleotide polymorphisms or SNP) have been discovered. Yet generally their contribution to increased T2D risk is small and have negligible value in clinical practice to aid T2D treatment, categorize patie...

Introduction: Pregnant women are at risk for selenium deficiency, which is known to maintain adequate function of immune system and thyroprotective enzymes. Same, iodine is an essential micronutrient for thyroid hormone synthesis and important endocrine regulator of early brain development. Our previous study revealed that 81% of pregnant women in Latvia have insufficient levels of iodine. The aim of the present study was to evaluate iodine and selenium supply during pregnancy...

Objective: The most common type of pituitary diseases are pituitary adenomas (PA) of different origin. Although non-metastasizing, they still cause increased mortality and morbidity. Clinically significant PAs affect around 0.1% of population during lifetime. Circulating cell free DNA (ccfDNA) is approximately 165 bp long DNA fragments which are released in bloodstream upon cell death. ccfDNA has been used to investigate presence and properties of various cancers. Data on ccfD...