Endocrine Abstracts

Background and aim: The role of derangements of nitric oxide (NO) metabolism in the pathogenesis of complications of type 1 diabetes mellitus (T1D) is not sufficiently clear. There is little data on simultaneous measurements of NO metabolites nitrite and nitrate (NO2/NO3) in urine and serum in T1D. Data about the measurement of NO production by electronparamagnetic spectroscopy (EPR) in whole blood in T1D were never published. To fill this gap we have cha...

Introduction: Metabolic syndrome (MetS), the combination of obesity, glucose metabolism impairment, dyslipidemia and high blood pressure, is becoming a worldwide burden of morbidity and mortality. Both genetic and enviromental factors are involved in its pathogenesis, with heritability of each component of MetS 25–80%.Aim: We aim to contribute to dissection of the genetic architecture of MetS using PD (polydactylous) rats, which present a unique mi...