Searchable abstracts of presentations at key conferences in endocrinology

ea0070aep563 | Pituitary and Neuroendocrinology | ECE2020

Macrophages involvement in neuroendocrine tumor behaviour and progression

Boemi Ilena , Vitali Eleonora , Trivellin Giampaolo , Smiroldo Valeria , Lavezzi Elisabetta , Zerbi Alessandro , Stratakis Constantine , Lania Andrea

Neuroendocrine neoplasms (NENs) are rare tumour showing a wide spectrum of clinical behaviours. Therapeutic options available for NET treatment are rarely curative and mostly palliative, as NETs frequently show resistance to pharmacological therapy. Cancers develop in complex tissue environments, which they depend on. Tumour-associated macrophages (TAMs) are a major cellular component of the tumour microenvironment. Two polarized state of macrophages are described in literatur...

ea0081ep594 | Endocrine-Related Cancer | ECE2022

New CDKN1b mutation in multiple endocrine neoplasia type 4 and brief literature review on clinical management.

Brunetti Alessandro , Lavezzi Elisabetta , Bertuzzi Alexia , Nappo Gennaro , Laffi Alice , Pedicini Vittorio , Vitali Eleonora , Trivellin Giampaolo , Mazziotti Gherardo , Lania Andrea

Background: The fourth type of Multiple Endocrine Neoplasia (MEN) is a rare variant of MEN presenting a MEN1-like phenotype and originating from a germline mutation in CDKN1B. However, due to the small number of cases documented in literature, the peculiar clinical features of MEN4 are still largely unknown, and clear indications about the clinical management of these patients are currently lacking. In order to enlarge our knowledge on MEN4 and to better typify the clinical fe...

ea0070aep666 | Pituitary and Neuroendocrinology | ECE2020

Surgical and clinical outcome in elderly patients affected by non-functional pituitary adenoma treated by endoscopic transnasal transsphenoidal surgery: A monocentric study

Biamonte Emilia , Milani Davide , Lavezzi Elisabetta , Betella Nazarena , Cellini Miriam , Battista Lasio Giovanni , Mazziotti Gherardo , Lania Andrea

The rate of diagnosis of pituitary adenomas in the elderly is increasing, as a consequence of the improved life expectancy. The management of elderly patients affected by pituitary adenomas are still a subject of debate in literature. In particular, data on the safety of endoscopic transnasal transsphenoidal surgery (TNS) are still controversial. The primary endpoint of the present study is to assess the surgical outcome of a cohort of patients who underwent TNS for non-functi...

ea0070aep724 | Pituitary and Neuroendocrinology | ECE2020

Metformin and everolimus: A promising combination for neuroendocrine tumors treatment

Vitali Eleonora , Boemi Ilena , Piccini Sara , Tarantola Giulia , Zerbi Alessandro , Smiroldo Valeria , Lavezzi Elisabetta , Spada Anna , Mantovani Giovanna , Lania Andrea

Treatment options for neuroendocrine tumors (NET), including everolimus, are rarely curative, as NETs frequently show resistance to medical therapy. In fact, the use of everolimus, an mTOR inhibitor, is limited by the development of resistance, probably due to the activation of Akt signalling. Metformin seems to have anticancer effects in neuroendocrine tumors (NETs). A recent retrospective study found longer progression-free-survival in diabetic pancreatic neuroendocrine tumo...

ea0070aep578 | Pituitary and Neuroendocrinology | ECE2020

Association between sagittal spine imbalance and radiological vertebral fractures in acromegaly: Does it reflect a pathophysiological link?

Cellini Miriam , Biamonte Emilia , Trenti Nicoletta , Mazza Massimiliano , Milani Davide , Ferrante Emanuele , Lavezzi Elisabetta , Mantovani Giovanna , Arosio Maura , Fornari Maurizio , Balzarini Luca , Lania Andrea , Mazziotti Gherardo

Chronic exposure to GH hypersecretion may alter the physiological balance of the spine through inducing degeneration of intervertebral discs and impaired trophism of facet joints. Moreover, GH in excess may also cause profound deterioration in bone microstructure with consequent increase in risk of fragility vertebral fractures (VFs). In this cross-sectional study,we evaluated for the first time in acromegaly the association between spine imbalance and VFs. Thirty-eight patien...

ea0070aep954 | Thyroid | ECE2020

TNM 8th edition in thyroid cancer staging: Is there an improvement in predicting recurrence?

Cellini Miriam , Alice Manzardo Olimpia , Indirli Rita , Dolci Alessia , Colombo Paolo , Carrone Flaminia , Lavezzi Elisabetta , Mantovani Giovanna , Mazziotti Gherardo , Arosio Maura , Lania Andrea

TNM 8th edition introduces changes in the staging of patients with differentiated thyroid carcinoma (DTC). This study aims at assessing the ability of TNM 8th edition in predicting structural recurrence of DTC.480 DTC patients were retrospectively evaluated by 7th and 8th editions of TNM staging systems in relationship with risk stratification, response to therapy and recurrence of disease as defined by 2015 American Thyroid Association (ATA) guidelines. As compared to the 7th...

ea0075r06 | Reproductive Endocrinology | EYES2021

Low testosterone is a predictor of hypoxemic respiratory insufficiency and higher mortality rate in SARS-CoV-2 hospitalized patients: A cohort study

Vena Walter , Pizzocaro Alessandro , Maida Giulia , Amer Myriam , Voza Antonio , Di Pasquale Andrea , Reggiani Francesco , Ciccarelli Michele , Fedeli Carlo , Lavezzi Elisabetta , Mazziotti Gherardo , Lania Andrea

Objective: To evaluate the association between testosterone (T) values and clinical outcome of COVID-19.Methods: This is a retrospective single-center study performed on 221 male patients (median age 70.5 years, range 26-93) with COVID-19 and hospitalized in our Institution between November 1st 2020 and January 31st 2021. PatientsÂ’ height, weight, BMI, medical history and comorbidities were recorded; at admission, patients underwent sampling for com...

ea0093oc16 | Oral communication 3: Adrenal Tumors and Neuroendocrine Tumors | EYES2023

Bone fragility in well-differentiated gastroenteropancreatic-neuroendocrine tumors: Results from a retrospective two-centered study

Brunetti Alessandro , Jaafar Simona , Chiardi Isabella , Cellini Miriam , Salcuni Antonio Stefano , Pigni Stella , Lavezzi Elisabetta , Lania Andrea , Mazziotti Gherardo , Vescini Fabio

Background: Patients affected by gastroenteropancreatic-neuroendocrine tumors (GEP-NETs) present an increased risk of bone fragility due to several factors, such as bone metastases, vitamin D deficiency, hormonal secretion, medical and surgical treatments. Although patients with well-differentiated GEP-NETs generally present a long life-expectancy, occurrence of fragility fractures could significantly impair quality of life.Objectives: The study aims to ...

ea0081ep668 | Pituitary and Neuroendocrinology | ECE2022

A multicenter retrospective study on a large cohort of patients with primary empty sella: hormonal and neuroradiological features over a long follow-up

Carosi Giulia , Brunetti Alessandro , Mangone Alessandra , Baldelli Roberto , Tresoldi Alberto , Sindaco Giulia Del , Lavezzi Elisabetta , Sala Elisa , Mungari Roberta , Fatti Letizia Maria , Galazzi Elena , Ferrante Emanuele , Indirli Rita , Biamonte Emilia , Arosio Maura , Cozzi Renato , Gerardo Antonio Lania Andrea , Mazziotti Gherardo , Mantovani Giovanna

Background: primary empty sella (ES) represents a frequent finding (up to 35% of the general population). According to the literature, the prevalence of hypopituitarism in ES ranges between 19-52%. Data on the natural history of ES over a long time, especially in incidental ES, are still lacking and the management can be challenging.Objective: our primary aim was to assess in a large cohort of patients with ES the prevalence and determinants of hypopitui...

ea0090p381 | Endocrine-related Cancer | ECE2023

Gender related differences in patients with carcinoid syndrome: new insights from a multicenter retrospective study

Grazia Tarsitano Maria , Altieri Barbara , Grossrubatscher Erika , Minotta Roberto , Zamponi Virginia , Albertelli Manuela , Appetecchia Marialuisa , Pia Brizzi Maria , Vittoria Davi Maria , Fanciulli Giuseppe , Giannetta Elisa , Guarnotta Valentina , La Salvia Anna , Lania Andrea , Lavezzi Elisabetta , Malandrino Pasqualino , Mazzilli Rossella , Modica Roberta , Pia Anna , Prinzi Natalie , Pusceddu Sara , Razzore Paula , Zanata Isabella , Chiara Zatelli Maria , Isidori Andrea , Maria Colao Anna , Faggiano Antongiulio , Maddalena Ruggeri Rosaria

The incidence of Neuroendocrine Neoplasm (NEN) and related carcinoid syndrome (CS) increased markedly in recent decades, and women appear to be more at risk than men. As per other tumors, gender may be relevant in influencing the clinical and prognostic characteristics. Unfortunately, there are no studies designed to answer this question in the literature. The present multicentric study was designed to evaluated gender differences, if any, in clinical presentation and outcomes...