Searchable abstracts of presentations at key conferences in endocrinology

ea0081ep427 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

The role of deferoxamine (DFO) in insulin resistance and diabetes

Ahn So-Yeon , Woo Song Min , Yeop Jeong Jae , Ho Kim Tae , Choi Sung-E , Kang Yup , Jin Kim Hae , Young Jeon Ja , JIN Han Seung , Lee Nami , Lee Kwan-Woo

Iron also plays an important role in many physiological processes, including redox balance, inflammation, and metabolism. It is reported perturbation of iron (Fe) homeostasis has also been associated with metabolic diseases. Iron reduction, with iron chelator, has preventive effects in cardiovascular remodeling and obesity. On the other hand, deferoxamine (DFO) increases hypoxia and collagen production in the kidney. Thus, the effects of DFO on metabolic disease remains contro...

ea0081p66 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

The role of empagliflozin in palmitate-induced ER stress and apoptosis in H9C2 cells

Jeong Jae Yeop , Choi Sung-E , Song Min Woo , Ho Park Suck , Kang Yup , Ho Kim Tae , Ahn So-Yeon , Jin Kim Hae , jin Han Seung , Jeon Ja Young , Lee Nami , Jung Kim Dae , Lee Kwan-Woo

Aim/hypotheses: Ectopic lipid accumulation in the heart contributes to the abnormal function of the heart and to the death of cardiomyocytes. Saturated FFA is one of the most important causes of death in cardiomyocytes. Although empagliflozin has been reported to be beneficial for people with diabetic complications and/or CVD, it has not been confirmed as to how it affects cardiomyocytes death by FFA. This study was designed to evaluate the protective effects of SGLT2 inhibito...