Searchable abstracts of presentations at key conferences in endocrinology

ea0059mte6 | Gender dysphoria | SFEBES2018

Gender dysphoria: Treatment and out comes

Seal Leighton

Introduction: The incidence of people presenting to gender services is increasing rapidly the case load appears to double every 5 years.This equates to a an estimated incidence of between 1:7440(10) to 1:30,000 for natal males and 1:31,153(10) to 1:10000 for natal females making this a relatively common disorder. The aim of therapy is threefold to suppress the production of the natal sex steroids, provide sufficient hormone levels for the development of the secondary sexual ch...

ea0031cmw2.3 | How Do I Do It? | SFEBES2013

How do I monitor and follow up transgender patients using hormonal therapies?

Seal Leighton

Gender identity disorder is not a rare condition occurring in 1:7440 born male and 1:31 153 born female individuals. Although gender transition is supervised in specialist clinics, post transition the patients are discharged back to primary or secondary care follow up. In my session I will discuss the process of gender transition, common hormonal regimens used and their monitoring. I will also discuss safety studies and the monitoring of long term follow up of individuals taki...

ea0059ep75 | Neuroendocrinology and pituitary | SFEBES2018

Unusual cause of meningioma

Nizar Hisham , Seal Leighton

Case: 60 year old transfemale had normal delivery, milestones and puberty. She developed gynaecomastia aged 14, associated obesity which resolved. As an adult she had reduced facial and body hair and reduced sexual function prior to hormone therapy but normal self-reported genitalia. She has female role from age of 24. She never had any children and was commenced female hormones 36 years ago. These were Premarin and Cyproterone Acetate which were continued post genital reconst...

ea0028p86 | Clinical practice/governance and case reports | SFEBES2012

Isolated HSV infection in Waterhouse-Friderichsen syndrome

Anthonypillai Fiona , Seal Leighton

A 59 year old women presented to the accident and emergency department with tachycardia and hypotension following a one day history of feeling unwell. She was peripherally shutdown, cyanosed, hypoxic, had a purpuric rash and numbness to her fingers. CT scan revealed bilateral adrenal haemorrhage consistent with Waterhouse-Friderichsen syndrome. This was further confirmed with a Short synacthen test(SST) showing a peak 30 minute cortisol of 102 nmol/l. She was commenced on oral...

ea0044p101 | Diabetes and Cardiovascular | SFEBES2016

Effect of testosterone replacement in hypogonadal men with type 2 diabetes in routine clinical practice

Sidhu Baljinder Kaur , Chinnasamy Eswari , Seal Leighton

Approximately 25–40% of men with type 2 diabetes suffer from hypogonadism, mostly mixed type. Despite a clear association between diabetes and hypogonadism, the exact mechanism is not completely understood; insulin resistance, elevated oestradiol and inflammatory mediators may all have key roles. Studies so far, are conflicting on the benefits of testosterone on metabolic parameters in these men. Hughes et al and meta-analysis by Cai et al showed a significant improvement...

ea0038p69 | Clinical practice/governance and case reports | SFEBES2015

Endometrial hyperplasia in transmen: to scan or not to scan?

Seal Leighton , Middleton Iffy , Barrett James

Endometrial hyperplasia has been reported in up to 15% of transmen. For this reason the current clinical practice suggest that the uterus should be scanned every 2 years.This is the single centre retrospective audit study at the largest UK Gender Identity Clinic to examine the incidence of endometrial hyperplasia in transmen.Between 2006 and 2012. 200 patients having been maintained on testosterone therapy for 2 years, of those 108...

ea0038p380 | Reproduction | SFEBES2015

Self medication in transpeople is not associated with deterioration in cardiovascular risk factors but is associated with reduced vitamin D levels and antidepressant use

Seal Leighton , Khaleque Fahmin , Barrett James

Objective: This is a prospective audit looking at cardiovascular parameters in transpeople comparing those who have self medicated verses those who have not.Methods: Patients attending a workshop for new patients were questioned about cardiovascular risk factors including diabetes hypertension and smoking status. Measurements were made of lipid profile, glucose, blood pressure, waist, height and weight measurement. Those that were self medicating (SM) we...

ea0034p334 | Reproduction | SFEBES2014

Oestrogen implant improves symptoms of hypogonadism and lipid profile in transwomen

Kyaw Ye , Espina Maricel , Seal Leighton

Background: Oestrogen replacement therapy is essential in transwomen for their well-being. Various forms of oestrogen therapy are available. Individual responses to such replacement therapy may vary. Hormonal implant is a reliable form of hormone replacement in postmenopausal women. However, their efficacy and safety in transwomen have not been thoroughly examined yet.Methods: 14 transwomen had 100 mg of oestradiol implant inserted subcutaneously in the ...

ea0034p335 | Reproduction | SFEBES2014

Testosterone implant therapy: efficacy and safety in transmen and native men with hypogondism

Kyaw Ye , Espina Maricel , Seal Leighton

Background: Various forms of testosterone replacement therapy has been used in replacement therapy for transmen and men with hypogonadism. However, efficacy and safety of testosterone implant has not been studied yet.Methods: 11 patietns (five transmen and six men with hypogonadism) had 800–1000 mg of testosterone implant inserted subcutaneously in the anterior abdominal wall. All subjects had previously been on other forms of testosterone replaceme...

ea0031p363 | Thyroid | SFEBES2013

Interferon-induced thyroid dysfunction: a case series

Sennik Devesh , Forton Daniel , Seal Leighton

Interferon use for the treatment of chronic hepatitis infection, is associated with the side effect of thyroid dysfunction. This is frequent and can be severe, particularly if not recognised. We performed a retrospective analysis of cases of interferon related thyroid dysfunction referred to our tertiary endocrinology centre. Fourteen cases were identified over the last 8 years. An analysis was carried out of demographic features, presentation, treatment and outcomes.<p cl...