Searchable abstracts of presentations at key conferences in endocrinology

ea0089o11 | Other | NANETS2022

Pheo Para Alliance Patient Centered Research on Challenges for Those with Pheochromocytoma and Paraganglioma

Rose-Krasnor Linda , Alband Stephanie , W. M. Lenders Jacques , Fishbein Lauren

Background: Patients with pheochromocytoma/paraganglioma (PPGL) often face difficulties in obtaining timely and accurate diagnosis, as well as in accessing experienced specialists. However, little is known about the experiences of patients in obtaining effective care.Methods: To address this gap and give voice to the patients, we invited potential participants, through social media, email, and the PheoPara Alliance (PPA) website, to complete a 20-min onl...

ea0063p823 | Adrenal and Neuroendocrine Tumours 3 | ECE2019

Pheochromocytoma affecting Pregnancy: still searching the needle in the haystack?

Langton Katharina , Constantinescu Georgiana , Richter Susan , Gieldon Laura , Lenders Jacques , Eisenhofer Graeme

Introduction: Pheochromocytoma associated with pregnancy carries a great risk for adverse fetal and maternal outcome, especially when the diagnosis is missed. Symptoms can present in a wide variety regarding intensity and duration, making it difficult for the treating midwife or obstetrician to draw correct conclusions.Clinical Case: We present a case of a 29 years old patient whose third pregnancy was complicated by short, but frequent and intense spell...

ea0016p306 | Endocrine tumours | ECE2008

Distinct catecholamine phenotypes in hereditary pheochromocytoma

Eisenhofer Graeme , Lenders Jacques WM , Mannelli Massimo M , Bornstein Stefan R , Pacak Karel

This study examined whether different forms of hereditary pheochromocytoma are characterized by different catecholamine phenotypes and whether this is reflected by differences in plasma concentrations of normetanephrine, metanephrine and methoxytyramine – the respective O-methylated metabolites of norepinephrine, epinephrine and dopamine. Subjects included 154 patients with hereditary pheochromocytoma, 72 with tumors associated with von Hippel–Lindau (VHL) syndrome, ...

ea0063p56 | Adrenal and Neuroendocrine Tumours 1 | ECE2019

A difficult diagnosis: pheochromocytoma or methamphetamine abuse?

Constantinescu Georgiana , Leike Steffen , Kunath Carola , Langton Katharina , Gruber Matthias , Peitzsch Mirko , Deinum Jaap , Lenders Jacques , Eisenhofer Graeme

Introduction: Pheochromocytomas represent rare but potential lethal tumors arising from the adrenal medulla. Early recognition and diagnosis represent a challenge due to the non-specific character of signs and symptoms. The classic presentation includes headache, sweating, palpitations and other signs and symptoms of apparent catecholamine excess occurring in paroxysms. Sympathomimetics may result in a similar presentation, potentially complicating the diagnosis.<p class="...

ea0032p512 | Endocrine tumours and neoplasia | ECE2013

Biochemical diagnosis of pheochromocytoma using plasma free normetanephrine, metanephrine and methoxytyramine: importance of supine sampling under fasting conditions

Darr Roland , Peitzsch Mirko , Pamporaki Christina , Prejbisz Aleksander , Fassnacht Martin , Beuschlein Felix , Neumann Hartmut , Januszewicz Andrzej , Lenders Jacques , Eisenhofer Graeme

Objective: To document influences of sampling of blood under supine fasting versus seated non-fasting conditions on diagnosis of pheochromocytoma using plasma concentrations of normetanephrine, metanephrine and methoxytyramine (P-NMN/MN/MTY).Design and methods: P-NMN/MN/MTY were measured by liquid chromatography with tandem mass spectrometry in 695 patients at five centers, two of which complied with requirements for supine sampling after an overnight fa...

ea0038oc2.2 | Translational pathophysiology and therapeutics | SFEBES2015

Adrenal vein catecholamine levels and ratios: reference intervals derived from patients with primary aldosteronism

O'Toole Sam , Sze Candy , Tirador Kent , Akker Scott , Matson Matthew , Perry Les , Druce Maralyn , Dekkers Tanja , Deinum Jaap , Lenders Jacques , Eisenhofer Graeme , Drake William

Introduction: Phaeochromocytoma localisation is generally reliably achieved with modern imaging techniques, particularly in sporadic cases. Diagnostic doubt can arise due to the presence of bilateral adrenal abnormalities, particularly in patients with mutations in genes predisposing them to the phaeochromocytoma development. In such cases, surgical intervention is ideally limited to large or functional lesions due to the long-term consequences associated with hypoadrenalism. ...

ea0081oc6.1 | Oral Communications 6: Endocrine-Related Cancer | ECE2022

Recurrent disease in patients with sporadic pheochromocytoma and paraganglioma

Li Minghao , Prodanov Tamara , Meuter Leah , Kerstens Michiel , Bechmann Nicole , Prejbisz Aleksander , Fassnacht Martin , Timmers Henri , Beuschlein Felix , Fliedner Stephanie , Robledo Mercedes , Lenders Jacques , Pacak Karel , Eisenhofer Graeme , Pamporaki Christina

Background: It is well established that life-long follow-up is required for patients with hereditary pheochromocytomas and paragangliomas (PPGLs), due to the potential of developing recurrent disease. However, whether follow-up of patients with sporadic PPGLs is necessary, remains unclear.Aims: To examine the prevalence and predictors of recurrent disease in patients with sporadic PPGLs.Materials and method: This multicenter study included retrospective ...

ea0041gp9 | Adrenal | ECE2016

Is steroid profiling using LC-MS/MS useful in the diagnostic work-up of primary aldosteronism?

Williams Tracy A. , Lenders Jacques W.M. , Peitzsch Mirko , Dekkers Tanja , Dietz Anna S. , Rump Lars C. , Willenberg Holger S. , Treitl Marcus , Bidlingmaier Martin , Beuschlein Felix , Deinum Jaap , Eisenhofer Graeme , Reincke Martin

Introduction: Primary aldosteronism (PA) is mainly caused by unilateral aldosterone-producing adenomas (APA) or bilateral adrenal hyperplasia (BAH). Subtype differentiation relies on the invasive and technically challenging adrenal venous sampling (AVS). We recently demonstrated the potential utility of peripheral plasma steroid profiling by LC-MS/MS to distinguish APA and BAH. We tested the following hypotheses: first, if steroid profiling in combination with AVS, effectively...

ea0038oc1.6 | Early Career Oral Communications | SFEBES2015

Urine steroid metabolomics as a diagnostic tool in primary aldosteronism

Lang Katharina , Beuschlein Felix , Biehl Michael , Dietz Anna , Riester Anna , Hughes Beverly A , O'Neil Donna M , Hahner Stefanie , Quinkler Marcus , Lenders Jacques W , Shackleton Cedric H L , Reincke Martin , Arlt Wiebke

Introduction: The regular diagnostic workup for primary aldosteronism (PA) can be very demanding and involves multiple invasive as well as time and cost intensive diagnostic tests. Here we have explored the value of urinary steroid metabolome analysis in the diagnosis and differential diagnosis of PA. Previously, urinary 3α,5β-tetrahydroaldosterone (THAldo) has been suggested as a reliable screening test for PA and serum 18-oxocortisol and 18-hydroxycortisol have bee...

ea0032p8 | Adrenal cortex | ECE2013

Plasma metanephrine for assessing the selectivity of adrenal venous sampling

Dekkers Tanja , Deinum Jaap , Kool Leo Schultze , Blondin Dirk , Vonend Oliver , Hermus Ad , Peitzsch Mirko , Rump Lars , Antoch Gerald , Sweep Fred , Lenders Jacques , Bornstein Stefan , Willenberg Holger , Eisenhofer Graeme

Context: More reliable parameters than cortisol are needed for assessing correct catheter positioning during adrenal vein sampling (AVS). Plasma metanephrine represents one such alternative.Objective: To determine the utility of adrenal venous (AV) plasma concentrations of metanephrine to establish correct catheter positioning during AVS.Design and methods: We included 86 AVS procedures: 52 ACTH-stimulated and 34 non-stimulated seq...