Endocrine Abstracts

Background: The COMMODITY12 is a telemedicine system designed for continuous monitoring of diabetes type 1 (DM1) and DM2, as well as the cardiovascular comorbidities. The system has been created in collaboration of nine European academic and industrial partners under FP7 (www.commodity12.eu).Aim: The aim of this study was to assess clinical utility of the COMMODITY12 system in DM2 patients, under a design of a mini...

Design and methods: Though several new treatments for diabetes (DM) are available, their effectiveness, however, might be limited, by patients knowledge. In order to test patients’ knowledge and self-management of diabetes, we had employed a questionnaire for clinic patients with types 1 and 2 DM. This was a pilot study for a telemetric medicine EU project (www.COMMODITY12.eu). Study involved 37 subjects (19 males) with type 1 (n=18) or insulin treated type 2 DM ...

A 59-year-old female presented with apathy and 6 kg weight gain. Investigations revealed primary hypothyroidism (TSH >100 μIU/ml). Thyroxine (L-T4) was started and titrated up to 75 μg, o.d., with clinical improvement. Other investigations revealed high titres of anti-thyroid peroxidase and anti-thyroglobulin antibodies. After three months, there was a fall in TSH to 12.74 μIU/ml, however, with unexpectedly high free T4 (...

Background: ACTH concentrations remain typically elevated in patients with Addison’s disease. We present a case of an extremely potent oral contraceptive pill (OCP) induced increase in total cortisol resulting in inhibition of ACTH secretion that was normalized on OCP withdrawal.Case Presentation: A 20-year old female was diagnosed with Addison’s disease [cortisol 1.59 µg/dl, ACTH>500 pg/ml (0-65)] and...

Background: Amiodarone-induced thyrotoxicosis (AIT) is sometimes very difficult to treat. Pulse methylprednisolone in addition to oral steroids appears effective in treatment of AIT, but effects of such treatment may be transient.Presentation of The Case: A 65 year old man was admitted our Department because of drug-resistant AIT. He had a history of atrial fibrillation, treated with amiodarone since 2019, and NSTEMI myo...

Background: Amiodarone-induced thyrotoxicosis is sometimes extremely difficult to treat necessitating emergency thyroidectomy with perioperative risks including possible thyroid storm. We obtained near normalization of free T3 (FT3) by pulse Methylprednisolone prior to thyroidectomy for drug-resistant Amiodarone-induced thyrotoxicosis.Case Description: A 56 year old man (BMI 29.7 kg/m2), with history atrial flutter/fibrillation, episodes of fa...

Background: Vasopressin, secreted in equimolar amounts with copeptin, is implicated as a stimulus for ACTH secretion during dynamic tests, such as Glucagon Stimulation Test (GST) or Insulin Tolerance Test (ITT). Some individuals with intact ACTH-cortisol axis, demonstrate, however, a lack of further cortisol stimulation during GST. We have assessed whether failure of further ACTH-cortisol increase during GST may be associated with an inadequate vasopressin/copeptin release.</p...

Background: Self-administration of anabolic steroids among bodybuilders is an underestimated problem, often not admitted by patients.Case presentaation: A 19 year old male (planning to study medicine!) presented with gynaecomastia, general malaise and erectile problems. Investigations revealed acute hepatitis: ALT 2125 U/L [Ref. range (RR)<45] and hypogonadotropic hypogonadism: LH – 1.6 IU/L [RR: 1.5-9.3], testosterone 0.214 ng/mL [RR: 2.49-8.36...

Background: Neck irradiadion is associated with several complications including both hypo- and hyperthyroidism. We present a case of severe hypothyroidism, followed 5 years later by thyrotoxicosis.Case description: A 27-year-old female presented with clinical and biochemical thyrotoxicosis (TSH 0.01 μIU/ml (ref. range: 0.27–4.2 μIU/ml); FreeT4 1.58 ng/dl (ref. 0.98–1.63 ng/dl); FreeT3 4.56 pg/ml (ref. 2.6–4....

Background: The so called “big-big” prolactin, also known as macroprolactin is formed by prolactin-immunoglobulin complexes, and is considered to be biologically inactive. Nevertheless, macroprolactin may cause elevation of serum prolactin (Prl) concentrations measured by standard assays. In women presenting with oligo- and/or amenorrhoea the cause of menstrual irregularity needs to be explained even in the setting of concomitant macroprolactinaemia. We have therefor...