Searchable abstracts of presentations at key conferences in endocrinology

ea0037ep285 | Calcium and Vitamin D metabolism | ECE2015

Low extracellular sodium promotes adipogenic commitment of human mesenchymal stromal cells: a novel mechanism for chronic hyponatremia-induced bone loss

Deledda Cristiana , Fibbi Benedetta , Giuliani Corinna , Benvenuti Susanna , Luciani Paola , Mazzanti Benedetta , Saccardi Riccardo , Peri Alessandro

Hyponatraemia represents an independent risk factor for osteoporosis and fractures, affecting both bone density and quality. A direct stimulation of osteoclastogenesis and bone resorption in the presence of reduced extracellular sodium concentrations ([Na+]) has been shown, but, to date, the effects of reduced [Na+] on osteoblasts have not been elucidated. This study investigated the effects of a chronic reduction of extracellular [Na+], independently of osmotic stress, on hum...

ea0032p623 | Growth hormome IGF axis – basic | ECE2013

Low extracellular sodium causes neuronal distress independently of reduced osmolality in an experimental model of chronic hyponatremia

Deledda Cristiana , Luciani Paola , Benvenuti Susanna , Modi Giulia , Bossio Alessandro , Giuliani Corinna , Fibbi Benedetta , Peri Alessandro

Introduction: There is evidence that chronic mild hyponatremia (serum (Na+) 130–135 mmol/l) may have clinical consequences, such as fracture occurrence and neurological symptoms including unsteadiness, falls and attention deficits. These have been traditionally associated to water movement into nervous cells, as a result of the hypotonic state. The aim of the present study was to determine whether low extracellular sodium directly exerts negative effects on human neuronal...

ea0016oc1.7 | Neuroendocrinology and pituitary | ECE2008

Intermittent high glucose concentrations reduce neuronal precursor proliferation by altering the IGF system: the involvement of the neuroprotective factor seladin-1

Giannini Stefano , Pezzatini Anna , Luciani Paola , Manuelli Cinzia , Benvenuti Susanna , Cellai Ilaria , Deledda Cristiana , Vannelli Gabriella Barbara , Rotella Carlo Maria , Serio Mario , Peri Alessandro

The exposure of cells to high glucose concentrations is considered a determinant of diabetic neuropathy. Conversely, members of the Insulin-like Growth Factor (IGF) system are well known neurotrophic factors. Here, we investigated the effects of constant and intermittent high glucose concentrations on IGF-I and IGF Binding Proteins (IGFBPs) in human neuroblast long-term cell cultures (FNC). We first demonstrated that FNC express the IGF-I receptor, and express and release in t...

ea0014p530 | (1) | ECE2007

The expression of the neuroprotective factor seladin-1 is up-regulated by thyroid hormones in human neuronal precursor cells, but not in mature neurons

Benvenuti Susanna , Luciani Paola , Cellai Ilaria , Deledda Cristiana , Saccardi Riccardo , Urbani Serena , Vannelli Gabriella B , Francini Fabio , Squecco Roberta , Serio Mario , Pinchera Aldo , Peri Alessandro

Thyroid hormones (TH) play a fundamental role during brain development by modulating the expression of different genes involved in neuronal differentiation, proliferation, migration, myelinization, and synapse formation. Seladin-1 (for SELective Alzheimer’s Disease INdicator-1) is a recently identified anti-apoptotic gene, which has been found to be down-regulated in brain regions affected by Alzheimer’s disease (AD). We hypothesized that seladin-1 might be a ...