Searchable abstracts of presentations at key conferences in endocrinology

ea0060nets1 | Diagnostic and Management Challenges in NETs | UKINETS2018

New pathology classification in GEP-NENs

Luong Tu Vinh

The classification and nomenclature of neuroendocrine neoplasms (NENs) is complex, can be confusing and has undergone major changes over the last three decades, as illustrated by the evolution in classification of GEP-NENs by the WHO. The 4th edition of the WHO’s classification of GEP-NENs was published in 2010. This edition is currently in use for gastrointestinal neuroendocrine neoplasm (GI-NEN) classification. The WHO 2010 classification introduced a strict ...

ea0060oc3 | (1) | UKINETS2018

PUnNETS (Prediction of Unknown Neuroendocrine Tumour Site) – a DNA methylation-based classifier

Berner Alison M , Pipinikas Christodoulos , Karpathakis Anna , Dibra Harpreet K , Moghul Ismail , Webster Amy , Luong Tu Vinh , Thirlwell Christina

Neuroendocrine tumours (NETs) of unknown primary (UP-NETs) represent up to 22% of NETs. Primary site identification enables patients to access appropriate treatment but is not always possible by immunohistochemistry or imaging. Given the epigenetic dysregulation of NETs, we aimed to use methylation array data to determine UP-NET tissue-of-origin. DNA from formalin-fixed paraffin embedded tissue from 76 pancreatic NET (PanNETs) (54 training and 22 validation samples) and 53 sma...

ea0052oc2 | (1) | UKINETS2017

Systematic evaluation of the immune microenvironment of neuroendocrine tumours

Vesely Clare , Childs Alexa , Wong Yien Ning Sophia , Ogunbiyi Olagunju , Gander Amir , Luong Tu Vinh , Thirlwell Chrissie , Caplin Martyn , Peggs Karl , Marafioti Teresa , Quezada Sergio A. , Meyer Tim

Background: Immunotherapy is currently being explored in many tumour types with encouraging results, but has not yet been evaluated in neuroendocrine tumours (NET). Our aim is to characterise the immune landscape of NET and determine which immune-modulatory pathways control the tumour infiltrating lymphocytes (TILs) in order to develop a rational approach for immunotherapy in this tumour type.Methods: Peripheral blood and fresh tissue was obtained from c...

ea0052p29 | (1) | UKINETS2017

Endoscopic submucosal dissection (ESD) of gastric and rectal neuroendocrine tumours (NETs)

Murino Alberto , Bailey James , Telese Andrea , Laskaratos Faidon-Marios , Koukias Nikolaos , Vlachou Erasmia , Luong Tu Vinh , Mandair Dalvinder , Caplin Martyn , Toumpanakis Christos , Despott Edward

Background: Gastrointestinal (GI) neuroendocrine tumours (NETs) are potentially malignant lesions originating from the enterochromaffin cells of the GI tract. These neoplasms often produce characteristic hormonal syndromes and can cause debilitating symptoms. Endoscopic submucosal dissection (ESD) is a well-established, complex, endoscopic technique, which allows for full resection of the mucosal and submucosal lesions without the need for open surgery.M...

ea0052p33 | (1) | UKINETS2017

Double-balloon enteroscopy (DBE) is useful and effective for the diagnosis, assessment and management of small bowel neuroendocrine tumours (SBNETs): a case series from a national tertiary referral centre

Telese Andrea , Murino Alberto , Phillips Edward , Laskaratos Faidon , Luong Tu Vinh , Koukias Nikolaos , Mandair Dalvinder , Toumpanakis Christos , Caplin Martyn , Despott Edward

Background: Although small bowel (SB) neuroendocrine tumours (SBNETs) often present as indolent lesions, late diagnosis may result in poor outcomes. Successful management is therefore dependent on early identification. Double-balloon enteroscopy (DBE) enables direct SB mucosal visualisation, sampling and endotherapy. Our aim was to evaluate the role of DBE for early diagnosis and management of SBNETs.Methods: Retrospective review of all SBNETs diagnosed/...

ea0025s2.2 | Novel pathways and treatments in neuroendocrine tumours | SFEBES2011

Integrated genome-wide DNA methylation and mRNA expression analysis of pancreatic NETs

Thirlwell Christina , Schulz Laura , Eymard Marianne , Meyer Tim , Davidson Brian , Teschendorff Andrew , Jiao Yan , Luong Tu-Vinh , Caplin Martyn , Beck Stephan

Integration of genetics and epigenetics has emerged as a powerful approach to study cellular differentiation and tumourigenesis. The study of DNA methylation is of particular importance in cancer as causal involvement has been demonstrated and it is the most stable of all epigenetic modifications, making it a desirable marker for both early detection and treatment of tumours. Hypermethylation of CpG sites in gene promoter regions leads to decreased gene expression, if such a g...

ea0052oc3 | (1) | UKINETS2017

Incidence and prevalence of neuroendocrine tumours in England

Genus Tracey , Bouvier Catherine , Wong Kwok , Srirajaskanthan Rajaventhan , Rous Brian , Talbot Denis , Valle Juan , Khan Mohid , Pearce Neil , Elshafie Mona , Reed Nicholas , Luong Tu Vinh , Munir Alia , Ramage John

Introduction: Historically the incidence and prevalence of neuroendocrine tumours (NETs) has been difficult to establish due to issues with disease coding and data collection. Studies estimated the incidence of gastroenteropancreatic neuroendocrine tumours (GEP NETs) to be 1.3 per 100,000 per year (incidence hereafter given as cases per 100,000). However, the SEER USA data suggests a four-fold higher incidence, and prevalence of 35 per 100,000. This study aimed to identify the...

ea0052p12 | (1) | UKINETS2017

1-Year survival rates for neuroendocrine tumour patients in England

Genus Tracey , Bouvier Catherine , Wong Kwok , Srirajaskanthan Rajaventhan , Rous Brian , Talbot Denis , Valle Juan , Khan Mohid , Pearce Neil , Elshafie Mona , Reed Nicholas , Luong Tu Vinh , Munir Alia , Ramage John

Introduction: Accurate survival data for patients with neuroendocrine tumours (NETs) across the UK has been difficult to capture. Individual centres often report good survival rates, however, national data has not previously been available.Materials and methods: NET patient survival was calculated for England using the Public Health England (PHE) National Cancer Registration and Analysis Service (NCRAS) dataset which captures tumour stage using TNM stagi...

ea0052p13 | (1) | UKINETS2017

Metachronous primary cancers in neuroendocrine tumour patients

Genus Tracey , Bouvier Catherine , Wong Kwok , Srirajaskanthan Rajaventhan , Rous Brian , Talbot Denis , Valle Juan , Khan Mohid , Pearce Neil , Elshafie Mona , Reed Nicholas , Luong Tu Vinh , Munir Alia , Ramage John

Introduction: Historically there has been an association with neuroendocrine tumours (NETs) and other cancers. However, this has not previously been well characterised. We aimed to determine the incidence of second malignancies in patients with NETs and investigate any association of the anatomical site of NETs with other malignancies.Materials and methods: 12,844 patients were diagnosed with a NET between 2013 and 2015 and captured by the National Cance...

ea0052p19 | (1) | UKINETS2017

Mixed Adeno-Neuroendocrine Carcinoma (MANEC): a multicentre retrospective study

Frizziero Melissa , Wang Xin , Chakrabarty Bipasha , Childs Alexa , Luong Tu Vinh , Walter Thomas , Khan Mohid S. , Morgan Meleri , Christian Adam , Elshafie Mona , Shah Tahir , Fulford Paul , Minicozzi Annamaria , Mansoor Wasat , Meyer Tim , Hubner Richard A. , Valle Juan W. , McNamara Mairead G.

Introduction: MANEC is a rare diagnosis and little is known on its epidemiology/prognosis/management.Methods: Demographic/clinical-pathological/survival data of patients with a diagnosis of MANEC (2010 WHO criteria) from five European centres were retrospectively reviewed.Results: Sixty-six patients were identified (09/80–07/17); median age: 62.5 years (range 34–89); male: 66.7%; ECOG-PS 0-1: 59%; primary tumours from: sm...