Searchable abstracts of presentations at key conferences in endocrinology

ea0073aep22 | Adrenal and Cardiovascular Endocrinology | ECE2021

Impact of adrenal insufficiency on female sexual function: A preliminary study

Zamponi Virginia , Mazzilli Rossella , Maggio Roberta , Lardo Pina , Olana Soraya , Pugliese Giuseppe , Faggiano Antongiulio , Stigliano Antonio

IntroductionAdrenal insufficiency is a clinical condition that leads to depletion of glucocorticoids, mineralocorticoids and androgens. While in men adrenal androgen deficiency is not clinically significant for testicular testosterone synthesis, in women so far androgen treatment is suggested for the reduction of libido and depression. However, no data is currently available on female sexual function.Primary endpoints<p class="...

ea0081p391 | Endocrine-Related Cancer | ECE2022

Effect of mitotane on male gonadal function

Innocenti Federica , Di Persio Sara , Taggi Marilena , Maggio Roberta , Lardo Pina , Elena Aloini Maria , Canipari Rita , Stigliano Antonio

Mitotane (MTT) currently represents the treatment of choice for adrenocortical carcinoma (ACC). Clinical evidence shows the occurrence of hypogonadism following treatment with this drug, observed more frequently in male patients. The aim of the study, therefore, was to evaluate the impact of MTT treatment on male gonadal function on adult CD1 mice. At the end of the 45 days of treatment, testes were collected for morphological examination, and a blood sample of each animal was...

ea0070ep3 | Adrenal and Cardiovascular Endocrinology | ECE2020

Advantage and trustworthy of cortisol and dexamethasone evaluation in different biological matrices in patients with adrenal masses

Lionetto Luana , Maggio Roberta , Lardo Pina , De Bernardini Donatella , Cipolla Fabiola , Capi Matilde , Simmaco Maurizio , Pugliese Giuseppe , Stigliano Antonio

Biochemical function of adrenal masses is currently based on 1 mg post-overnight dexamethasone suppression test (pDST). Several approaches are recently developed, in order to reduce false positive/negative samples, only in retrospective series. They are based on the correlation of some different parameters, i.e. late-night salivary cortisol (LNSC) vs serum and salivary cortisol pDST; LNSC vs serum and salivary cortisol and serum dexamethasone pDST; LNSC and cortisone vs serum ...

ea0073aep28 | Adrenal and Cardiovascular Endocrinology | ECE2021

Effects of sorafenib, a tyrosin kinase inhibitor, on adrenocortical cancer cell line

Cerquetti Lidia , Bucci Barbara , Raffa Salvatore , Lardo Pina , Maggio Roberta , Simonini Chiara , Petrangeli Elisa , Toscano Vincenzo , Pugliese Giuseppe , Stigliano Antonio

The lack of an effective medical treatment for adrenocortical carcinoma (ACC) has prompted the, search for better treatment protocols for ACC neoplasms. Sorafenib, a tyrosine kinase inhibitor has exhibited effectiveness in the treatment of different human tumors. Therefore, the aim of this study was to understand the mechanism through which sorafenib acts on ACC, especially since treatment with sorafenib alone is sometimes unable to induce a long-lasting antiproliferative effe...

ea0081oc13.5 | Oral Communications 13: Adrenal and Cardiovascular Endocrinology 2 | ECE2022

Machine learning-based texture analysis in the characterization of cortisol secreting vs non secreting adrenocortical incidentalomas in CT scan

Maggio Roberta , Messina Filippo , D'Arrigo Benedetta , Maccagno Giacomo , Lardo Pina , Palmisano Claudia , Biondo Irene , Matarazzo Iolanda , Laghi Andrea , Pugliese Giuseppe , Stigliano Antonio

Adrenal nodular disease is a frequently increasing in the general population with an incidence that reaches almost 10% in the seventh decade of life. More and more evidences show these lesions discovered through diagnostic imaging (CT, MRI) performed for other medical problems (incidentalomas). New radioimaging techniques, exploiting the quantitative variables of imaging, permit to identify an hypothetical pathological tissue. We have applied this potential in a retrospective ...