Searchable abstracts of presentations at key conferences in endocrinology

ea0031p181 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2013

The role of hepatic 11β-hydroxysteroid dehydrogenase type 1 in cholesterol homeostasis

Manwani Kajal , Man Tak Y , Kenyon Christopher J , Andrew Ruth , Chapman Karen E , Seckl Jonathan R

11β-Hydroxysteroid dehydrogenase type one (11β-HSD1) converts inert glucocorticoids to active forms, amplifying intracellular glucocorticoid action. 11β-HSD1 also catalyses the reduction of seven-ketocholesterol (7KC) to 7β-hydroxycholesterol (7βHC). 7KC may inhibit cholesterol biosynthesis (Brown et al. 2002). Alteration of cholesterol homeostasis is a major atherosclerotic risk factor. 11β-HSD1 deficiency/inhibition is atheroprotective ...

ea0031p189 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2013

The role of glucocorticoid metabolism in bile acid homeostasis

Opiyo Monica Naomi , Kenyon Christopher , Manwani Kajal , Man Tak , Seckl Jonathan , Andrew Ruth , Chapman Karen

Background and aims: Bile acids regulate cholesterol metabolism and the digestive system. They are conserved through enterohepatic circulation, a glucocorticoid-modulated process. We investigated whether the regeneration of active glucocorticoid by 11β-hydroxysteroid dehydrogenase type one (11β-HSD1) affects bile acid release and enterohepatic transport after re-feeding.Methods: Bile acid turnover was assessed in global (Hsd11b11<...

ea0025p156 | Diabetes, metabolism and cardiovascular | SFEBES2011

Attenuated atherosclerosis in 11β-hydroxysteroid dehydrogenase type 1 deficient ApoE−/− mice is associated with reduced aortic VCAM-1 expression and reduced MCP-1 in the visceral fat

Kipari Tiina , Man Tak-Yung , Hadoke Patrick , Savill John , Chapman Karen , Seckl Jonathan

11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) regenerates glucocorticoids in intact cells, converting inert cortisone into active cortisol. We have previously shown attenuated atherosclerosis development, reduced plasma monocyte chemoattractant protein-1 (MCP-1) and reduced macrophage/T cell infiltration within atherosclerotic lesions in 11β-HSD1−/−×ApoE−/− double knock-out (DKO) mice fed western diet (WD)....

ea0021p182 | Diabetes and metabolism | SFEBES2009

Deficiency in 11β-hydroxysteroid dehydrogenase type 1 reduces systemic inflammation and inflammatory cell infiltration in atherosclerotic lesions of ApoE−/− mice

Kipari Tiina , Man Tak-Yung , Hadoke Patrick , White Christopher , Chapman Karen , Seckl Jonathan

High plasma levels of glucocorticoids cause metabolic disease (central obesity, hypertension, diabetes) and increase risk of cardiovascular disease. 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) regenerates glucocorticoids in intact cells, converting inert cortisone (11-dehydrocorticosterone in rodents) into active cortisol (corticosterone in rodents). Recent work has shown the pathological importance of elevated adipose tissue 11β-HSD1 expression in develo...

ea0015oc27 | Pituitary, disease | SFEBES2008

Adipose GR knockdown protects against obesity in female mice

Marshall Elaine , Man Tak Yung , Morton Nicholas , Kenyon Christopher , Seckl Jonathan , Chapman Karen

Obesity, particularly abdominal (visceral) obesity, is a major risk factor for development of the metabolic syndrome. Human and animal studies have shown elevated intra-adipose glucocorticoid-action in obesity and suggest that increased glucocorticoid receptor (GR) density may be an important determinant of visceral adiposity. We have tested this hypothesis in transgenic (Tg) mice in which adipose GR levels have been increased or decreased, by expression of “sense” o...

ea0044oc1.2 | Early Career Oral Communications | SFEBES2016

11β-HSD1 deficiency modulates brain energy homeostasis during acute systemic inflammation

Verma Manu , Kipari Tiina , Man Tak Yung , Forster Thorsten , Homer Natalie , Seckl Jonathan , Holmes Megan , Chapman Karen

Chronically elevated glucocorticoid (GC) level impairs cognition. In rodents, elevated plasma GC levels, prior to an inflammatory challenge, potentiates neuroinflammation that is abolished by GR but not MR antagonism. 11β-hydroxysteroid dehydrogenase type-1 (11β-HSD1) increases intracellular GC levels by regenerating active GCs from inert forms. Inhibition/deficiency of 11β-HSD1 is protective against age-related cognitive decline presumably by lifelong reduced b...