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ea0070aep880 | Thyroid | ECE2020

Clinical practice survey on BRAF V600E role in the therapeutic decision in indeterminate thyroid cytology

Brigante Giulia , Craparo Andrea , Pignatti Elisa , Marino Marco , Casarini Livio , Sperduti Samantha , Boselli Gisella , Margiotta Gianluca , Rochira Vincenzo , Simoni Manuela

Introduction: The use of multigene panels in thyroid nodule diagnosis is still limited, due to high costs and need for ad hoc sampling. Since BRAF-V600E is the commonest genetic alteration in differentiated thyroid cancer, this is the mostly tested genetic parameter in clinical practice.Aim: To evaluate the use of BRAF mutation analysis in wash-out liquid from fine needle aspiration (FNA) in clinical practice, characterizing th...

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ea0081oc11.1 | Oral Communications 11: Thyroid 2 | ECE2022

Thr92Ala polymorphism of the type 2 deiodinase (DIO2) is associated with higher risk of iatrogenic thyrotoxicosis in thyroidectomized subjects treated with levothyroxine and liothyronine

Boselli Gisella , Margiotta Gianluca , Corleto Rossella , Monzani Maria Laura , Craparo Andrea , Locaso Michela , Sperduti Samantha , Simoni Manuela , Rochira Vincenzo , Santi Daniele , Brigante Giulia

Introduction: Hypothyroidism treatment is classically based on levothyroxine (LT4). However, 10% of hypothyroid patients treated with LT4 complain of hypothyroidism symptoms, despite normal thyroid stimulating hormone (TSH) serum levels. This peripheral hypothyroidism has been linked to decreased availability of free triiodothyronine (fT3), likely related to single nucleotide polymorphisms (SNP) in deiodinase genes (DIO), reducing enzymatic activity. Since...

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ea0090oc2.1 | Oral Communications 2: Thyroid | ECE2023

Randomized double-blind placebo-controlled trial on levothyroxine and liothyronine combination therapy: The levolio study

Brigante Giulia , Santi Daniele , Boselli Gisella , Margiotta Gianluca , Corleto Rossella , Monzani Maria Laura , Craparo Andrea , Locaso Michela , Sperduti Samantha , Roy Neena , Casarini Livio , Trenti Tommaso , Varani Manuela , De Santis Maria Cristina , Roli Laura , Rochira Vincenzo , Simoni Manuela

Introduction: Despite normal thyroid-stimulating hormone serum levels, up to 60% of hypothyroid patients are dissatisfied with the treatment. Animal studies suggest that the persistence of symptoms may derive from peripheral hypothyroidism. Combination treatment with levothyroxine and liothyronine is a theoretically plausible solution but its efficacy is still questionable.Aim: To evaluate the effects of personalized twice-daily combination therapy on pe...

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Endocrine Abstracts

Clinical practice survey on BRAF V600E role in the therapeutic decision in indeterminate thyroid cytology

Thr92Ala polymorphism of the type 2 deiodinase (DIO2) is associated with higher risk of iatrogenic thyrotoxicosis in thyroidectomized subjects treated with levothyroxine and liothyronine

Randomized double-blind placebo-controlled trial on levothyroxine and liothyronine combination therapy: The levolio study

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