Endocrine Abstracts

Several lines of evidence indicate an increased risk of adverse gestational outcomes in women with Hashimoto’s thyroiditis (HT) already as of TSH levels at early pregnancy >2.5mU/l, and definitely greater for TSH concentration >4mU/l. The latest guidelines recommend preconception TSH levels (pre-C-TSH) in HT women be maintained below 2.5mU/l, this threshold being expected to prevent hypothyroidism occurrence at early gestation.Objectives: To...

Context: Chronic hypercortisolism is known to impact the hypothalamus-pituitary-thyroid (HPT) axis, through a disruption of both thyrotropin-releasing-hormone and thyroid-stimulating hormone (TSH) release. These changes, in turn, are responsible for reduced triiodothyronine (T3) and thyroxine (T4) synthesis and secretion, eventually resulting in central hypothyroidism (C-Hypo). However, data on magnitude and timing of recovery of the above abnormalities are still controversial...

Background and objectives: Recent data on median urinary iodine concentration (UIC) in schoolchildren showed that Italy has achieved iodine sufficiency. Nevertheless, no national data on iodine nutrition in pregnancy are available. Therefore, a multicentre study coordinated by the Italian National Observatory for Monitoring Iodine Prophylaxis (OSNAMI), was launched in 8 Italian regions representative of the Northern (Lombardy, Veneto, Liguria), Central (Tuscany, Lazio) and Sou...

Background and objectives: In the period 2022-2023, a multicentre study coordinated by the Italian National Observatory for Monitoring Iodine Prophylaxis (OSNAMI), was launched in 8 Italian regions representative of the Northern (Lombardy, Veneto, Liguria), Central (Tuscany, Lazio) and Southern Italy and Islands (Sicily, Calabria, Sardinia) with the aim of evaluating iodine nutrition in pregnant women (n = 400/region) and thyroid function in the offspring. Here we pre...