Searchable abstracts of presentations at key conferences in endocrinology

ea0012p126 | Thyroid | SFE2006

Identifying risk factors for relapse in Graves’ disease: a retrospective study

Jivanjee A , Martin NM , Meeran K

Graves’ disease typically follows a relapsing and remitting course. Most patients with recurrent hyperthyroidism after withdrawal of antithyroid drugs (ATDs) are offered definitive treatment with radioactive iodine. This retrospective study aimed to identify clinical and biochemical indices that predict relapse following ATD withdrawal, which could allow earlier definitive treatment to be initiated.We studied 70 patients with Graves’ disease wh...

ea0012p118 | Steroids to include Cushing's | SFE2006

Current practice regarding the diagnosis of Cushing’s disease: Survey at the European Congress of Endocrinology 2006

Llewellyn R , Martin NM , Meeran K

In ACTH-dependent Cushing’s syndrome, the high dose dexamethasone suppression test (HDDST) has been traditionally used to identify differentiate between pituitary-dependent Cushing’s disease and ectopic ACTH production. However, more recently, concerns regarding the diagnostic accuracy of the HDDST have led to many centres abandoning this test in preference to bilateral inferior petrosal sinus sampling (IPSS). We aimed to establish current consensus in the UK for the...

ea0044p212 | Reproduction | SFEBES2016

Gonadotrophin secretion is a useful adjunct in the diagnosis of patients with hyperprolactinaemia

Clarke S , Abbara A , Nesbitt A , Ali S , Comninos AN , Hatfield E , Martin NM , Sam A , Meeran K , Dhillo W

Background: Hyperprolactinaemia accounts for 1 in 7 patients presenting with amenorrhoea. Recent data suggests that prolactin acts at the hypothalamus to reduce GnRH-pulsatility. Conditions in which GnRH-pulsatility is reduced, such as hypothalamic amenorrhoea, favour FSH over LH secretion from the pituitary gland. We examined gonadotrophin secretion in hyperprolactinaemic patients as a surrogate marker of GnRH-pulsatility.Methods: A retrospective analys...

ea0019p101 | Clinical practice/governance and case reports | SFEBES2009

Severe obstructive sleep apnoea causing a pseudo-Cushing's state

Bravis V , Todd J , Dhillo W , Martin NM , Tan T , Meeran K

A 59-year-old lady presented with significant weight gain, and a history of hypertension for investigation of possible Cushing’s syndrome. Her BMI was 29, with mainly central obesity. Initial tests revealed elevated untimed cortisol on two separate occasions, at 905 nmol/l and 893 respectively with detectable midnight cortisol, at 548 and 481. Of 24-hour urinary free cortisol (UFC) was also elevated on two separate occasions, at 931 nmol/24 h and 827 respectively. ACTH wa...

ea0019p271 | Pituitary | SFEBES2009

The challenges in managing prolactinomas in patients with psychiatric illness treated with antipsychotic medication

Mehta SR , McGowan BMC , Ghaffar A , Shaikh H , Martin NM , Hatfield ECI , Meeran K

Antipsychotic induced hyperprolactinaemia, mediated by blockade of dopamine D2 receptors, is much more common than prolactinoma in patients receiving antipsychotic medication. We present two cases of the latter.Case 1: A 47-year-old gentleman with depression treated with amitriptyline, fluoxetine and risperidone presented with headaches and a left sided visual field defect. Pituitary MRI showed a 2 cm macroadenoma abutting the optic chiasm. Prolactin was...

ea0019p272 | Pituitary | SFEBES2009

A single early morning serum cortisol in the early post operative period following transphenoidal surgery for pituitary tumours accurately predicts hypothalamo–pituitary–adrenal function

Jayasena CN , Gadhvi KA , Gohel B , Martin NM , Mendoza N , Meeran K , Dhillo WS

Background: Secondary adrenal insufficiency is a common complication of transsphenoidal hypophysectomy (TSS) for pituitary adenoma. It is therefore imperative to rapidly and accurately identify patients requiring glucocorticoid replacement, thus minimising risks of adrenal insufficiency or unnecessary glucocorticoid exposure. The gold-standard test of HPA axis reserve, the insulin tolerance test (ITT), cannot be performed safely until after post-operative recovery. Nine am cor...

ea0008oc9 | Neuroendocrinology and Reproduction | SFE2004

Triiodothyronine Directly Regulates Feeding

Martin NM , Kong WM , Smith KL , Gardiner JV , Small CJ , Ghatei MA , Bloom SR

The increased appetite associated with hyperthyroidism is assumed to be secondary to an increased metabolic rate. However, the role of thyroid hormones in appetite regulation is poorly understood. We hypothesised that thyroid hormones directly regulate food intake and studied the effects of peripheral and CNS administration of tri-iodothyronine (T3) on food intake in male Wistar rats in vivo.A single subcutaneous (s.c.) injection of 4.5 nmol per ...

ea0008p52 | Endocrine Tumours and Neoplasia | SFE2004

Multiple hepatic embolisations are an effective treatment for metastatic gastrinoma

Martin NM , Morganstein DL , Higham CE , Jackson J , Todd JF , Meeran K

A 55 year old lady presented to our hospital in 1991 with a year's history of diarrhoea, weight loss and abdominal pain. On examination, she had 5cm hepatomegaly. Serum gastrin was elevated (148 pmol per litre NR < 40), as was GAWK (276 pmol per litre NR < 150). Basal gastric acid secretion was increased (39 mmol per hour NR < 5). CT abdomen showed multiple hepatic metastases, confirmed to be neuroendocrine in origin on biopsy. There were no clinical or biochemical fe...