Endocrine Abstracts

Background: Bone marrow fat is a unique fat depot that is regulated independently of other fat depots. Estradiol is an important regulator of bone marrow fat. This is illustrated by an increase in marrow fat fraction after menopause and a decrease following estradiol replacement. We hypothesize that estradiol is the major sex steroid that regulates bone marrow fat not only in women, but also in men.Methods: This is an open-label partly randomized interve...

Introduction: Transgender women on gender-affirming hormone therapy (GAHT) with estrogens and anti-androgens have low serum androgen levels. These low levels may be associated with clinical symptoms such as depressed mood, reduced sexual desire and tiredness. Whether androgen levels change over the course of anti-androgen use and after gonadectomy, in a context of unchanged estrogen treatment, remains to be elucidated.Methods: This study is part of the E...