Searchable abstracts of presentations at key conferences in endocrinology

ea0090p216 | Thyroid | ECE2023

UPLC-Q-TOF/MS-based metabolomics explored the metabolic mechanisms of thyroid cancer in different background

Sun Danyang , Li Xue , Wang Xuan , Ji Yanhui , Meng Zhaowei , Zheng Wei

Thyroid papillary carcinoma (PTC) is the most common endocrine tumor, HashimotoÂ’s thyroiditis (HT) is considered to be closely related to PTC pathogenesis, but their relationship still needs verification and exploration. Aim of the study. To analyze the differences and similarities of the metabolic mechanism of thyroid papillary carcinoma in normal and HT background, and to explore the relationship between HT and PTC. The Ultra performance liquid chromatography-q...

ea0073oc10.4 | Oral Communications 10: Thyroid | ECE2021

Targeting TSHR and ICAM-1 for treatment of Graves’ disease in BALB/c mice

Zheng Wei , Wang Xuan , Li Wang , Wang Shen , Tan Jian , Jia Qiang , Meng Zhaowei , Rui Zhongying

ObjectiveIn BALB/c mice with GD model, the TSHR and ICAM-1 were targeted for treatment, and new approaches to GD targeted therapy were explored.MethodsThe siRNA targeting TSHR and the ICAM-1 mAb specifically binding ICAM-1 were designed and synthesized. Thirty GD model mice were randomly divided into siRNA treatment group, ICAM-1 mAb treatment group, and untreated GD group, with 10 mice in each group, and 10 ...