Searchable abstracts of presentations at key conferences in endocrinology

ea0015p217 | Pituitary | SFEBES2008

The man with two concurrent pituitary tumours

Satish Artham , Gorick Sondra , Michael Powell , Dhatariya Ketan

A 43-year-old man presented with aching legs, gynaecomastia, erectile dysfunction, central obesity, and generalised hair loss. Examination confirmed these findings as well as showing him to be hypertensive at 160/100 mmHg. Routine haematology and biochemistry as well as levels of anterior pituitary hormones were normal, except for an inappropriately low TSH in the face of normal T3 and T4 levels. A pituitary MRI showed the presence of an ill defined area of reduced signal inte...

ea0084op-04-21 | Oral Session 4: Basic 1 | ETA2022

CRYO-electron microscopy structures of human thyroid peroxidase (TPO) in complex with tpo antibodies

Baker Stuart , Nunez Miguel Ricardo , Thomas Daniel , Powell Michael , Furmaniak Jadwiga , Rees Smith Bernard

Objectives: Thyroid peroxidase (TPO) is a key enzyme in the synthesis of thyroid hormones and is a target for autoimmune responses in autoimmune thyroid disease. TPO autoantibody (TPOAb) binding epitopes have been mapped on the peroxidase domain (POD) and the complement control protein like domain (CCP). This study aimed to solve the molecular structures of TPO bound to TPO antibodies.Methods: An extracellular domain (ECD) of human TPO (amino acids; aa 1...

ea0037ep785 | Pituitary: clinical | ECE2015

Interpretation of dynamic test results in secondary hypocortisolism post pituitary surgery and hydrocortisone replacement doses

Theodoraki Aikaterini , McAlpine Christopher , Dawnay Anne , Dorward Neil , Powell Michael , Grieve Joan , Baldeweg Stephanie

Background: Following pituitary surgery, dynamic testing with insulin tolerance (ITT) or glucagon stimulation testing (GST) is used to identify patients with secondary hypocortisolism who require glucocorticoids. High glucocorticoid replacement doses are associated with adverse effects, and the optimal replacement dose is unknown.Aim: We aimed to assess the interpretation of dynamic testing post pituitary surgery in clinical practice and its relation wit...

ea0022p570 | Neuroendocrinology and Pituitary (<emphasis role="italic">Generously supported by Novartis</emphasis>) | ECE2010

The presentation of sellar and parasellar tumours in Uzbekistan

Ismailov Said , Grossman Ashley , Powell Michael , Khadjibaev Abdukhakim , Urmanova Yulduz , Shakirova Mukhlisa

Aim: To analyse the epidemiology and presentation of pituitary tumours in Uzbekistan.Materials and methods: Over a period of 1.5 years, we studied 53 consecutive patients with tumours in the sellar and suprasellar region (mean age 41.5 years) in terms of neurological and ophthalmological status, MRI imaging and detailed neuroendocrine functional assessment. A detailed examination of the sellar area by means of computer and magnetic resonance tomography w...

ea0022p580 | Neuroendocrinology and Pituitary (<emphasis role="italic">Generously supported by Novartis</emphasis>) | ECE2010

Incidence and dynamics of visual disturbances in hypothalamus and pituitary mass lesions after transphenoidal surgery in the Republic of Uzbekistan

Ismailov Said , Grossman Ashley , Powell Michael , Khalimova Zamira , Urmanova Yulduz , Makhkamov Kozim , Narimova Gulchekhra , Akbutaev Alisher

Aim of the research: To study the visual complications rate in patients with different pituitary adenomas.Patients and methods: We observed 24 patients with different pituitary adenomas, among them 14 women and 10 men. Mean age of patients was 36.4 years-old. According to the ethiology pattern patients were divided as follow; 17 patients with non-functioning pituitary adenomas, 1 patient with craniopharingioma, 2 patients with Cushing disease, 2 patients...

ea0020p215 | Endocrine tumours and neoplasia | ECE2009

Neuroendocrine disorders of patients with pituitary tumours

Ismailov Said , Makhkamov Kozim , Powell Michael , Grossman Ashley , Khalimova Zamira , Urmanova Yulduz

Aim: Aim of research is to study special features of pituitary adenoma (PA).Materials and methods: Seventy-four operations on CST were performed. Outcomes of surgery in 66 patients with PA were analyzed. Age of patients at surgery was from 18 to 71 years. Mean age of patients – 44 years. Four patients (6%) had a corticotropinoma, 11 patients (17%) had somatotropinoma, 11 patients (17%) had prolactinoma and remaining 40 patients (60%) had non-functio...

ea0063p237 | Pituitary and Neuroendocrinology 1 | ECE2019

Some risk factors of re-growth of non-functional pituitary adenomas in patients with growth hormone deficiency

Urmanova Yulduz , Grossman Ashley , Khalimova Zamira , Powell Michael , Korbonits Marta , Shakirova Mukhlisa , Pankiv Vladimir , Alieva Dinara , Tursunkulov Ortikali

Aim: The aim of investigation to determine clinical aggressiveness diagnostic markers in patients with non-functional pituitary adenomas (NFPA), and growth hormone deficiency (GHD) in the formation of gravity neuroendocrine disease symptoms.Material and methods: We observed in 87 patients (including man – 44 women – 43) of which have a verified diagnosis of NFPA after surgery – 31 which were subjected transnasal adenomectomy of the pituiat...

ea0049gp195 | Pituitary &amp; endocrine Tumours | ECE2017

Long-term follow-up of a family with a large AIP gene deletion: variable phenotypes and challenges in the management

Marques Pedro , Dang Mary , Ogilvie Arla , Storr Helen , Powell Michael , Grieve Joan , Evason Jane , Kumar Ajith , Korbonits Marta

Introduction: Germline aryl hydrocarbon receptor-interacting protein (AIP) mutations are responsible for 15–30% of familial isolated pituitary adenomas (FIPA). We report a 4-generation FIPA kindred with a heterozygous AIP gene deletion in exon 2, highlighting the benefits of genetic screening and management challenges in affected subjects and asymptomatic carriers.Patients: A 45y woman died of a spinal ependymoma (obligate carrier)...

ea0048o2 | Oral Communications | SFEEU2017

Metastatic pituitary carcinoma in an SDHB mutation positive patient

Tufton Nicola , Roncaroli Federico , Hadjudemetriou Irene , Dang Mary N , Denes Judit , Guasti Leonardo , Thom Maria , Powell Michael , Baldeweg Stephanie E , Fersht Naomi , Korbonits Marta

Case history: A 63-year-old female presented with bi-temporal hemianopia. Pituitary MRI demonstrated a macroadenoma with suprasellar extension. Her medical history included a glomus tumour of the right ear treated with external beam radiotherapy (EBRT) 25 years previously. She had no evidence of pituitary hormone abnormality and had normal urinary metanephrines levels. She underwent transsphenoidal surgery with total resection and full recovery of her visual fields. Immunohist...

ea0028p236 | Pituitary | SFEBES2012

Evaluation of the expression of vesicular protein (SNARE) isoforms in human pituitary adenomas

Garcia Edwin , Trivellin Giampaolo , Michael Powell , Grieve Joan , Sabin Ian , Alusi Ghassan , Louis Pobereskin , Shariati Babak , Roncaroli Federico , Mendoza Nigel , Grossman Ashley , Harper Elaine , Korbonits Marta

Background: Botulinum neurotoxin inhibits muscle function by interfering with neurotransmitter release from secretory vesicles. The mechanism underlying this effect involves cleavage of SNARE proteins which are required for vesicle docking at the plasma membrane. The ability of botulinum neurotoxin serotypes to cleave SNARE proteins and inhibit secretion is being exploited for therapeutic purposes by Syntaxin Ltd with their ‘targeted secretion inhibitor technology’ (...