Endocrine Abstracts

Introduction: Glycoprotein gp91-phox is an essential component of the NADPH oxidase. The superoxide-generating NADPH oxidase is present in phagocytes, neuroepithelial bodies, vascular smooth muscle cells and endothelial cells. It includes a membrane-bound flavocytochrome containing two subunits, gp91-phox and p22-phox. gp91-phox is a significant element of the membrane-bound oxidase of phagocytes that generates superoxide. It is the terminal component of a respiratory chain th...

Introduction: Thyroid goiter may be present in different thyroid pathologies, such as non-toxic nodular goiter (NTNG) or Hashimoto’s thyroiditis (HT), as a result of focal hyperplasia of thyrocytes (nodal goiter) or generalized enlargement of thyroid (diffuse goiter). Previous studies have demonstrated that programmed cell death, known as apoptosis, plays an important role in the pathogenesis of many thyroid diseases, especially inflammatory conditions.<p class="abste...

Introduction: Endocrine disorders can influence the hemostatic balance. Various abnormalities of coagulation-fibrinolytic system have been reported in patients with thyroid dysfunction. The aim of the study was to assess the immunohistochemical expression and distribution of coagulation and fibrinolysis markers in follicular cells of thyroid goiter.Materials and methods: 20 patients with thyroid goiter were included in the study: 11 cases with non-toxic ...