Searchable abstracts of presentations at key conferences in endocrinology

ea0022s20.2 | The endocrine incidentaloma | ECE2010

Pituitary incidentalomas

Coculescu Mihail

Current issues relating to pituitary incidentalomas include definitional limits, difficulties in their diagnosis resulting in hidden dangers, unknown pathogeny and management based on expectation. The prevalence of pituitary incidentalomas depends on the method of investigation: 3.2–27% in necroptic studies or 10–23% by imaging (MRI or CT), compared to only 0.1% clinically expressed pituitary adenomas. Diagnosis requires at least imaging and hormonal assays. However,...

ea0037ep1221 | Clinical Cases–Pituitary/Adrenal | ECE2015

Two treatment patterns of thyrotropinomas with over 3-year follow-up

Coculescu Mihail , Vintila Madalina

Introduction: Thyrotropinomas are rare pituitary tumours. Neurosurgery is considered the first-line treatment, followed by medical therapy with somatostatin analogues or radiotherapy.Case reports: We present two cases of thyrotropinomas with different therapeutic approaches. Case 1: A 63-year old man presented with severe thyrotoxicosis. Biochemical evaluation showed inappropriate TSH secretion (TSH=7.5 mU/l, FT4=45.5 pmol/l); computed tomogra...

ea0022p853 | Thyroid | ECE2010

Marked sensitivity of pituitary feedback to levothyroxine in asymptomatic primary autoimmune hypothyroidism

Trifanescu Raluca-Alexandra , Coculescu Mihail

Background: Few cases of hypersensitivity of thyroid–pituitary feedback in hypothyroid children were reported.Aim: To present a family with asymptomatic, severe biochemical primary autoimmune hypothyroidism who showed a marked sensitivity of pituitary feedback to levothyroxine treatment.Methods: TSH was measured by 3rd generation immunoassay kit.Case report: R.G, woman, aged 22, presented for asymptomati...

ea0020p340 | Diabetes and Cardiovascular | ECE2009

Limits in using brain natriuretic peptide (BNP) as a biomarker of acute right ventricular dysfunction in pulmonary embolism

Pascu Alina Mihaela , Radoi Mariana , Coculescu Mihail

Background: Risk stratification could be lifesaving in acute pulmonary embolism (PE). Echocardiographic (ECHO) acute right ventricular dysfunction (RVD) is the actual ‘gold standard’ in risk assessment of patients with PE. We previously demonstrated that plasma BNP levels were significantly higher in patients with PE and acute RVD on ECHO versus patients with normal right ventricular (RV) function on ECHO.Aim and objective: Evaluation of the li...

ea0026p638 | Clinical case reports | ECE2011

Hyponatremic coma with seizures as onset of isolated ACTH deficiency

Trifanescu R A , Stoicescu A , Caragheorgheopol A , Hortopan D , Coculescu Mihail

Introduction: Isolated acquired ACTH deficiency is rare; it may be due to hypophysitis and association with other autoimmune diseases was reported.Case report: E.L, female, aged 34, was diagnosed with primary autoimmune hypothyroidism and premature ovarian failure; levothyroxine and estroprogestins were administered. Suddenly, the patient developed vomiting, shivers without fever and soon coma installed, with tonic-clonic seizures. There was no history o...

ea0022p164 | Cardiovascular endocrinology and lipid metabolism | ECE2010

Correlation of plasma B-type natriuretic peptide (BNP) levels with electrocardiographic (ECG) signs of right ventricular strain in patients with acute pulmonary embolism

Mihaela Pascu Alina , Radoi Mariana , Bobescu Elena , Coculescu Mihail

Background: We previously demonstrated plasma BNP to be a valuable biomarker of right ventricular dysfunction (RVD) in patients with acute pulmonary embolism (PE). Several specific ECG abnormalities related to the right ventricular strain were described in patients with PE.Objective: Assessment of the correlation of plasma BNP levels with ECG signs of RVD in patients with PE.Methods: Seventy patients with confirmed acute PE, 42(60%...

ea0022p631 | Neuroendocrinology and Pituitary (<emphasis role="italic">Generously supported by Novartis</emphasis>) | ECE2010

Correlation between GH and FSH in the cerebrospinal fluid and sleep respiratory events

Capatina Cristina , Niculescu Dan , Caragheorgheopol Andra , Coculescu Mihail

Introduction: There are high levels of anterior pituitary hormones in the cerebrospinal fluid (CSF), i.e. beyond the blood–brain barrier, in many patients with pituitary tumors.Aim: To assess the influence of CSF pituitary hormones on brain functions reflected by sleep architecture and sleep apnea.Method: Twenty-nine patients (17 women, 12 men) with pituitary adenomas (20 acromegaly, 5 nonfunctioning pituitary adenomas, 4 prol...

ea0020oc4.2 | Acromegaly/IGF1/Type 2 Diabetes | ECE2009

Both insulin resistance and insulin secretion are involved in the pre-diabetes of acromegaly

Niculescu Dan , Purice Mariana , Lichiardopol Radu , Coculescu Mihail

In acromegalic patients growth hormone (GH) excess induces insulin resistance but whether this is sufficient, in the face of normal insulin secretion, for pre-diabetes (impaired fasting glucose (IFG) and impaired glucose tolerance (IGT)) to occur is a matter of debate.Aim: To assess the relative role of insulin resistance and insulin secretion in the pre-diabetes of acromegaly.Methods: One hundred and twenty-four patients with acro...

ea0020p224 | Endocrine tumours and neoplasia | ECE2009

Lanreotide effects on glucose metabolism in evolutive acromegaly in remission during chemotherapy

Galoiu Simona , Purice Mariana , Hortopan Dan , Dumitrascu Anda , Coculescu Mihail

Lanreotide has long been used in the therapy of GH secreting pituitary adenomas and other somatostatin receptor positive neuroendocrine tumors.Aims: To determine the impact on glucose metabolism of the 6 months of lanreotide therapy, beside of the antisecretory and antiproliferative effects.Patients and methods: Seven patients with active acromegaly treated with lanreotide, admitted in the Department of Neuroendocrinology, Institut...

ea0020p559 | Neuroendocrinology, Pituitary and Behaviour | ECE2009

Plurihormonal cells are more frequent in early embryofetal stages of the human pituitary

Chirculescu Andy RM , Morris John F , Coculescu Mihail GR

Our initial studies suggested that plurihormonal cells are constantly found in early embryonic stages of human pituitary but are very rare later.Aim: A quantitative evaluation and morphological characterization of these plurihormonal cells.Methods: Pituitaries from therapeutically aborted human fetuses of 8–24 weeks, gestational age were fixed (with ethical permission) by immersion in 4% buffered formaldehyde. One-μm-thic...