Endocrine Abstracts

Background: Solitary fibrous tumor of pleura represents a prototypical mesenchymal neoplasm that induces non-islet cell tumor hypoglycemia due to overproduction of insulin-like growth factor 2, named Dodge Potter syndrome.Case Presentation: An 86-year-old man, non-diabetic, was admitted to hospital with a few months history of repetitive hypoglycemic symptoms and documented low blood glucose of 1.9 and 1.2 mmol/L on two occasions when he lost consciousne...

Background: The coronavirus disease 2019 (COVID-19) can involve multiple organs and systems, including the endocrine system. In particular, thyroid dysfunctions are frequently seen in COVID-19 patients. The aim of this study was to evaluate thyroid function in hospitalized COVID-19 patients and to correlate thyroid function with inflammatory status, blood count parameters and mortality.Materials and methods: Data of COVID-19 patients admitted to the hosp...

Citrus flavanone naringenin (NAR) is a potent antioxidant with ability to change pituitary-thyroid function. NAR increases concentration of thyroid-stimulating hormone (TSH) in serum by increasing Sirtuin1 expression in the pituitary thyrotrophs and improves thyroid hormonogenesis capacity in old-aged rats. Thyroid hormone production is followed by generation of large quantities of reactive oxygen species (ROS) which are essential for iodine organification. A master regulator ...

Soy isoflavone daidzein exerts some beneficial effects in different ageing-related, chronic diseases and may represent a promising alternative to classical estrogenization of the prostate cancer suffering subjects. The aim of this study was to examine the effects of daidzein on the adrenocortical vascular network and hormonal output in a rat model of the mild andropause. Adult (3 months old) Wistar rats were divided into sham-operated (SO; n=7), orchi...

Calcitonin (CT) is a hypocalcemic hormone produced by thyroid C-cells that acts as an bone antiresorptive agent. The other endocrine cell population in thyroid, called follicular cells produce thyroid hormones (TH) which also affect bone turnover. In this study, we evaluated the effects of salmon CT administration on structure and function of both CT and TH producing thyroid cells as well as trabecular bone microarchitecture in orchidectomized (Orx) middle-aged rats. Fifteen-m...

Hypercholesterolemia is associated with athero-thrombotic disease, a leading cause of mortality worldwide. Advances in both dietary and pharmacological interventions contribute to prevention and treatment of modifiable risk factors.Purified soybean phytoestrogens, isoflavones genistein (GEN) and daidzein (DAI), were reported to exert moderate cholesterol-lowering effect. In this research first we studied age-related modifications in hepatic cholesterol metabolism and serum est...