Searchable abstracts of presentations at key conferences in endocrinology

ea0035p1018 | Thyroid (non-cancer) | ECE2014

Oxidative stress in patients with Basedow–Graves' disease

Petrulea Mirela

Basedow–Graves’ disease is an autoimmune disorder and the most frequent cause of hyperthyroidism.Increased thyroid hormone concentrations change cellular oxidative metabolism, determining the formation of reactive oxygen species.Objectives: To study oxidant–antioxidant status and the effect of antithyroid drugs on oxidative stress parameters in Basedow–Graves’ disease patients.Materials and methods: The stu...

ea0063p1183 | Thyroid 3 | ECE2019

Challenges of thyroid cancer management in amiodarone treated patients: a case report

Petrulea Mirela Sanda , Piciu Doina , Georgescu Carmen

Introduction: Thyroid carcinoma (TC) is the most common endocrine malignancy. Although the overall prognosis for patients with TC is good, up to 20% of patients develop recurrent or persistent disease after conventional therapy by total thyroidectomy and radioactive iodine (RAI). Amiodarone is a highly efficient anti-arrhythmic drug with a very long half-life, so it may interfere with RAI many months after the drug withdrawal. This case report mirrors the challenges of thyroid...

ea0022p763 | Thyroid | ECE2010

Effect of hyperthyroidism on parameters of oxidative stress and antioxidant status in Wistar rats

Petrulea Mirela Sanda , Duncea Ileana , Muresan Adriana

Introduction: Thyroid hormones are the most important factors involved in the regulation of the basal metabolic state, as well as in the oxidative metabolism. Oxidative stress accompanying hyperthyroidism is caused by increased synthesis of reactive oxygen species (ROS) and changes in the antioxidant defence system.Aim of the study: To evaluate the pro-oxidant/antioxidant status and the effect of vitamin E supplementation in damage caused by the excessiv...

ea0032p1029 | Thyroid (non-cancer) | ECE2013

Vitamin E supplementation in the treatment of Graves' disease

Petrulea Mirela Sanda , Ilie Ioana , Valea Ana , Ghervan Cristina , Georgescu Carmen , Login Cezar , Muresan Adriana , Duncea Ileana

Hyperthyroidism in the course of Graves’ disease leads to intensification of oxidative processes resulting in increased oxidative stress.Objectives: The effect of supplementation with vitamin E was monitored on the speed of attaining euthyroidism and on the oxidative stress parameters in patients with Graves’ disease, treated with thiamazole.Patients and methods: We examined 43 hyperthyroid patients and 12 euthyroid healt...

ea0041oc14.2 | Thyroid Cancer | ECE2016

Complex immunometabolic pathways mediate the interaction between thyroid carcinoma cells and tumor-associated macrophages

Arts Rob , Plantinga Theo , Heinhuis Bas , Tuit Sander , Petrulea Mirela , Tesselaar Marika , Sloot Yvette , Kusters Benno , Joosten Leo , Georgescu Carmen , Smit Johannes , Netea Mihai , Schulze Joakim , Netea-Maier Romana

Background: Tumor-associated macrophages (TAMs) with dysregulated inflammatory phenotypes play a key role in carcinogenesis. In thyroid carcinoma (TC), excessive release of proinflammatory cytokines decreases the expression of sodium-iodine transporter and inflammation potentiates tumor progression.Aim: To assess the impact of TC cells on the functional reprograming of TC-induced macrophages at the level of transcriptome and metabolic pathways, and asses...