Searchable abstracts of presentations at key conferences in endocrinology

ea0038fp4 | (1) | SFEBES2015

GLP-1 reduces cerebrospinal fluid secretion and intracranial pressure: a novel treatment for idiopathic intracranial hypertension?

Botfield Hannah , Uldall Maria , Mitchell James , Gonzalez Ana Maria , Jensen Rigmor , Sinclair Alexandra

Background: Idiopathic intracranial hypertension (IIH) predominantly affects obese women of childbearing age. IIH is characterised by increased intracranial pressure (ICP) which results in visual loss and disabling headaches. ICP dis-regulation results from imbalance of cerebrospinal fluid (CSF) production rate (at the choroid plexus epithelial cells) and drainage. Treatments for IIH are limited but weight loss is established as disease modifying.Glucago...

ea0034p111 | Clinical practice/governance and case reports | SFEBES2014

A rare case of Cushing's syndrome caused by ‘cyclical’ ectopic ACTH secretion

Behary Preeshila , Kadiyala Raghunath , Falinska Agnieszka , Beckwith Hannah , Jackson James , Mitchell Catherine , Todd Jeannie F

A 61-year-old lady presented with rapid onset of lethargy and reduced mobility with inability to use stairs over 1 month. Prior to this, she was fit and well and was a lifelong non-smoker. At presentation, she was overweight and had evidence of skin bruising and severe proximal myopathy of her legs. A midnight cortisol was >1710 nmol/l with a corresponding ACTH of 610 nmol/l confirming ACTH dependent CushingÂ’s syndrome. Serum potassium was 2.6 mmol/l and a new diagnos...

ea0050oc3.3 | Obesity, Diabetes Thyroid | SFEBES2017

The GLP-1R agonist exendin-4 reduces cerebrospinal fluid secretion and intracranial pressure

Botfield Hannah , Uldall Maria , Westgate Connar , Mitchell James , Hagen Snorre , Maria Gonzalez Ana , Hodson David , Jensen Rigmor , Sinclair Alexandra

Background: Current therapies for reducing raised intracranial pressure (ICP) in conditions such as idiopathic intracranial hypertension have limited efficacy and tolerability. As such, there is a pressing need to identify novel drugs. Glucagon-like peptide-1 receptor (GLP-1R) agonists are used to treat diabetes and promote weight loss but have also been shown to affect fluid homeostasis in the kidney. Here, we investigate whether exendin-4, a GLP-1R agonist, is able to modula...

ea0050oc3.3 | Obesity, Diabetes Thyroid | SFEBES2017

The GLP-1R agonist exendin-4 reduces cerebrospinal fluid secretion and intracranial pressure

Botfield Hannah , Uldall Maria , Westgate Connar , Mitchell James , Hagen Snorre , Maria Gonzalez Ana , Hodson David , Jensen Rigmor , Sinclair Alexandra

Background: Current therapies for reducing raised intracranial pressure (ICP) in conditions such as idiopathic intracranial hypertension have limited efficacy and tolerability. As such, there is a pressing need to identify novel drugs. Glucagon-like peptide-1 receptor (GLP-1R) agonists are used to treat diabetes and promote weight loss but have also been shown to affect fluid homeostasis in the kidney. Here, we investigate whether exendin-4, a GLP-1R agonist, is able to modula...

ea0050p320 | Obesity and Metabolism | SFEBES2017

Androgen excess is highly prevalent in women with idiopathic intracranial hypertension and is biochemically distinct from polycystic ovary syndromes

O'Reilly Michael , Hornby Catherine , Westgate Connar , Botfield Hannah , Markey Keira , Mitchell James , Jenkinson Carl , Gilligan Lorna , Sherlock Mark , Gibney James , Tomlinson Jeremy , Arlt Wiebke , Sinclair Alexandra

Idiopathic intracranial hypertension (IIH) is a condition of unknown aetiology characterised by raised intracranial pressure, chronic headaches and blindness. Akin to polycystic ovary syndrome (PCOS), IIH patients are almost exclusively obese females of reproductive age. A distinct androgen excess profile has been noted in PCOS. Here, we aimed to delineate androgen metabolism in IIH compared to PCOS and simple obesity.Women w...

ea0050p320 | Obesity and Metabolism | SFEBES2017

Androgen excess is highly prevalent in women with idiopathic intracranial hypertension and is biochemically distinct from polycystic ovary syndromes

O'Reilly Michael , Hornby Catherine , Westgate Connar , Botfield Hannah , Markey Keira , Mitchell James , Jenkinson Carl , Gilligan Lorna , Sherlock Mark , Gibney James , Tomlinson Jeremy , Arlt Wiebke , Sinclair Alexandra

Idiopathic intracranial hypertension (IIH) is a condition of unknown aetiology characterised by raised intracranial pressure, chronic headaches and blindness. Akin to polycystic ovary syndrome (PCOS), IIH patients are almost exclusively obese females of reproductive age. A distinct androgen excess profile has been noted in PCOS. Here, we aimed to delineate androgen metabolism in IIH compared to PCOS and simple obesity.Women w...