Endocrine Abstracts

Tumor angiogenesis is believed to result from an imbalance of pro- and anti-angiogenic factors. Angiogenesis is an important component in the development of thyroid goitre. Vascular endothelial growth factor (VEGF) and epidermal growth factor (EGF) represents a family of specific endothelial cell mitogens involved in normal angiogenesis and in tumor development. Consequently, a panel of anti-angiogenic factors was addressed in a representative sample of VEGF receptor-2 (VEGFR-...

Objective: The aim of this study was to evaluate the influence of subclinical and overt hyperthyroidism on the chosen markers of endothelial function.Material and methods: The groups studied consisted of 97 hyperthyroid subjects (51 with subclinical and 46 with overt hyperthyroidism) and 39 healthy controls matched for age, gender and body mass index. The following parameters were measured: TSH, FT3, FT4 (by MEIA), VCAM-1 (vascular cell adhesion molecule...

A higher incidence of nodular goitre and less differentiated types of thyroid carcinoma have been observed in iodine deficient regions. North-Eastern Poland was an area with a moderate deficiency of iodine until the introduction of the mandatory salt iodination in 1997 (30±10 mg KJ/kg NaCl). The aim of our study was to compare the incidence of goitre, thyroid carcinoma and urine excretion of iodine in the inhabitants of the North-Eastern Region of Poland in 1997 and 2005....